Biosynthesis of α-pyrones

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2016 Jun 25

PMID 27340449

Citations 29

Authors

Till F Schaberle

Affiliations

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Abstract

The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained. The purpose of this mini-review is to give a brief overview of α-pyrones and the mechanisms forming the basis of their natural synthesis. Especially the chain interconnecting enzymes, showing homology to ketosynthases which catalyze Claisen-like condensation reactions, will be presented.

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