SIRT1: A Promising Therapeutic Target for Chronic Pain

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2022 Apr 9

PMID 35396903

Authors

Fan-He Song

Dai-Qiang Liu

Ya-Qun Zhou

Wei Mei

Affiliations

Soon will be listed here.

Abstract

Chronic pain remains an unresolved problem. Current treatments have limited efficacy. Thus, novel therapeutic targets are urgently required for the development of more effective analgesics. An increasing number of studies have proved that sirtuin 1 (SIRT1) agonists can relieve chronic pain. In this review, we summarize recent progress in understanding the roles and mechanisms of SIRT1 in mediating chronic pain associated with peripheral nerve injury, chemotherapy-induced peripheral neuropathy, spinal cord injury, bone cancer, and complete Freund's adjuvant injection. Emerging studies have indicated that SIRT1 activation may exert positive effects on chronic pain relief by regulating inflammation, oxidative stress, and mitochondrial dysfunction. Therefore, SIRT1 agonists may serve as potential therapeutic drugs for chronic pain.

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