LINC01088 Promotes the Growth and Invasion of Glioma Cells Through Regulating Small Nuclear Ribonucleoprotein Polypeptide A Transcription

Overview

Journal Bioengineered

Date 2022 Apr 8

PMID 35392763

Authors

Tao Peng

Dong-Liang Chen

Shi-Lan Chen

Affiliations

Soon will be listed here.

Abstract

Altered long non-coding RNAs (LncRNAs) exert pivotal parts in pathogenic processes in glioma. Here, we uncovered a differentially expressed long intergenic non-coding RNA 1088 (LINC01088) in glioma and elucidated the molecular mechanism by which LINC01088 affected the malignant phenotypes of glioma cells. Functionally, LINC01088 silencing degraded cell proliferation, invasion in glioma, while LINC01088 overexpression elicited opposite results. Mechanistically, we verified LINC01088 physically interacted with small nuclear ribonucleoprotein polypeptide A (SNRPA) and regulated the expression of SNRPA at the transcription level. Phenotypic analysis ascertained that LINC01088 substantively aggravated glioma cell progression in an SNRPA-dependent manner, and SNRPA played a pivotal part in the tumor-promoting properties of LINC01088. Our findings revealed a novel mechanism by which LINC01088 exerted pro-oncogenic functions through binding with SNRPA and transcriptionally regulating SNRPA mRNA in glioma.

Citing Articles

The pathogenesis mechanism and potential clinical value of lncRNA in gliomas.

Liu Y, Yuan H, Fan J, Wang H, Xie H, Wan J Discov Oncol. 2024; 15(1):266.

PMID: 38967893 PMC: 11226588. DOI: 10.1007/s12672-024-01144-4.

Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging.

Qian J, Chen C, Zhao C, Xu X, Xu Y, Zhang Y Heliyon. 2023; 9(9):e19219.

PMID: 37662721 PMC: 10469075. DOI: 10.1016/j.heliyon.2023.e19219.

LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway.

Li J, Huang X, Chen H, Gu C, Ni B, Zhou J Mediators Inflamm. 2023; 2023:9207148.

PMID: 37501932 PMC: 10371595. DOI: 10.1155/2023/9207148.

Identifying Oxidized Lipid Metabolism-Related LncRNAs as Prognostic Biomarkers of Head and Neck Squamous Cell Carcinoma.

Zhang Z, Kim B, Han W, Chen X, Yan Y, Lin L J Pers Med. 2023; 13(3).

PMID: 36983670 PMC: 10054813. DOI: 10.3390/jpm13030488.

Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis.

Liang F, Luo Q, Han H, Zhang J, Yang Y, Chen J Acta Biochim Biophys Sin (Shanghai). 2023; 55(3):367-381.

PMID: 36942988 PMC: 10160232. DOI: 10.3724/abbs.2023021.

References

Schmitz S, Grote P, Herrmann B . Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 2016; 73(13):2491-509. PMC: 4894931. DOI: 10.1007/s00018-016-2174-5. View

Diao P, Ge H, Song Y, Wu Y, Li J, Li Z . Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma. J Cell Mol Med. 2019; 23(6):4269-4280. PMC: 6533490. DOI: 10.1111/jcmm.14318. View

Yu X, Lin Q, Liu F, Yang F, Mao J, Chen X . LncRNA TMPO-AS1 facilitates the proliferation and metastasis of NSCLC cells by up-regulating ERBB2 via sponging miR-204-3p. Int J Immunopathol Pharmacol. 2020; 34:2058738420958947. PMC: 7520928. DOI: 10.1177/2058738420958947. View

Jia R, Chai P, Wang S, Sun B, Xu Y, Yang Y . mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation. Mol Cancer. 2019; 18(1):161. PMC: 6854757. DOI: 10.1186/s12943-019-1088-x. View

Saw P, Xu X, Chen J, Song E . Non-coding RNAs: the new central dogma of cancer biology. Sci China Life Sci. 2020; 64(1):22-50. DOI: 10.1007/s11427-020-1700-9. View

Liu S, Dang H, Lim D, Feng F, Maher C . Long noncoding RNAs in cancer metastasis. Nat Rev Cancer. 2021; 21(7):446-460. PMC: 8288800. DOI: 10.1038/s41568-021-00353-1. View

Liu J, Feng Y, Zeng S, Zhong M . linc01088 promotes cell proliferation by scaffolding EZH2 and repressing p21 in human non-small cell lung cancer. Life Sci. 2019; 241:117134. DOI: 10.1016/j.lfs.2019.117134. View

Reon B, Anaya J, Zhang Y, Mandell J, Purow B, Abounader R . Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis. PLoS Med. 2016; 13(12):e1002192. PMC: 5140055. DOI: 10.1371/journal.pmed.1002192. View

Liu D, Zou Z, Li G, Pan P, Liang G . Long Noncoding RNA NEAT1 Suppresses Proliferation and Promotes Apoptosis of Glioma Cells Via Downregulating MiR-92b. Cancer Control. 2020; 27(1):1073274819897977. PMC: 6961147. DOI: 10.1177/1073274819897977. View

10.

Molinaro A, Taylor J, Wiencke J, Wrensch M . Genetic and molecular epidemiology of adult diffuse glioma. Nat Rev Neurol. 2019; 15(7):405-417. PMC: 7286557. DOI: 10.1038/s41582-019-0220-2. View

11.

Liang Y, Song X, Li Y, Chen B, Zhao W, Wang L . LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis. Mol Cancer. 2020; 19(1):85. PMC: 7206728. DOI: 10.1186/s12943-020-01206-5. View

12.

Fang Y, Fullwood M . Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics Proteomics Bioinformatics. 2016; 14(1):42-54. PMC: 4792843. DOI: 10.1016/j.gpb.2015.09.006. View

13.

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z . GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017; 45(W1):W98-W102. PMC: 5570223. DOI: 10.1093/nar/gkx247. View

14.

Cheng J, Meng J, Zhu L, Peng Y . Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications. Mol Cancer. 2020; 19(1):66. PMC: 7098115. DOI: 10.1186/s12943-020-01189-3. View

15.

Zhang Y, Zhang Y, Wang S, Cao B, Hu D, Jia J . LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p. Bioengineered. 2022; 13(2):3370-3382. PMC: 8973818. DOI: 10.1080/21655979.2021.2018098. View

16.

Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B . G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Sci. 2019; 110(11):3442-3452. PMC: 6825017. DOI: 10.1111/cas.14173. View

17.

Zhang W, Fei J, Yu S, Shen J, Zhu X, Sadhukhan A . LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p. Sci Rep. 2018; 8(1):2876. PMC: 5811426. DOI: 10.1038/s41598-018-21164-9. View

18.

Jiang Y, Cao W, Wu K, Qin X, Wang X, Li Y . LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus. J Exp Clin Cancer Res. 2019; 38(1):365. PMC: 6700841. DOI: 10.1186/s13046-019-1364-z. View

19.

Zheng Z, Li Z, Zhou G, Lin L, Zhang L, Lv J . Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3. Cancer Res. 2019; 79(18):4612-4626. DOI: 10.1158/0008-5472.CAN-19-0799. View

20.

Xing H, Sun H, Du W . LINC01116 accelerates nasopharyngeal carcinoma progression based on its enhancement on MYC transcription activity. Cancer Med. 2019; 9(1):269-277. PMC: 6943083. DOI: 10.1002/cam4.2624. View