Renal Cell Cancer and Obesity

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Mar 25

PMID 35328822

Authors

Anna Gluba-Brzozka

Jacek Rysz

Janusz Lawinski

Beata Franczyk

Affiliations

Soon will be listed here.

Abstract

Cancers are a frequent cause of morbidity and mortality. There are many risk factors for tumours, including advanced age, personal or family history of cancer, some types of viral infections, exposure to radiation and some chemicals, smoking and alcohol consumption, as well as obesity. Increasing evidence suggest the role of obesity in the initiation and progression of various cancers, including renal cell carcinoma. Since tumours require energy for their uncontrollable growth, it appears plausible that their initiation and development is associated with the dysregulation of cells metabolism. Thus, any state characterised by an intake of excessive energy and nutrients may favour the development of various cancers. There are many factors that promote the development of renal cell carcinoma, including hypoxia, inflammation, insulin resistance, excessive adipose tissue and adipokines and others. There are also many obesity-related alterations in genes expression, including DNA methylation, single nucleotide polymorphisms, histone modification and miRNAs that can promote renal carcinogenesis. This review focuses on the impact of obesity on the risk of renal cancers development, their aggressiveness and patients' survival.

Citing Articles

Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated with Increased Risk of Kidney Cancer: A Nationwide Study.

Oh J, Kim B, Yoon J, Lee H, Park H, Lee J Cancers (Basel). 2024; 16(18).

PMID: 39335133 PMC: 11430135. DOI: 10.3390/cancers16183161.

Renal Cell Carcinoma With Tumor Thrombus: A Case Series in Puerto Rico.

Bernaschina-Rivera S, Alayon-Rosario G, Dieppa-Barnes G, Encarnacion J, Ortiz-Sanchez C, Santini-Dominguez R Cureus. 2024; 16(4):e58113.

PMID: 38738111 PMC: 11088801. DOI: 10.7759/cureus.58113.

Inhibition of Pancreatic Lipase by Flavonoid Derivatives: and Investigations.

Tran T, Mai T, Ho T, Le T, Cao T, Thai K Adv Pharmacol Pharm Sci. 2024; 2024:6655996.

PMID: 38298460 PMC: 10830309. DOI: 10.1155/2024/6655996.

Complement System and the Kidney: Its Role in Renal Diseases, Kidney Transplantation and Renal Cell Carcinoma.

Lasorsa F, Rutigliano M, Milella M, Ferro M, Pandolfo S, Crocetto F Int J Mol Sci. 2023; 24(22).

PMID: 38003705 PMC: 10671650. DOI: 10.3390/ijms242216515.

The Association between Dietary Inflammatory Potential and Urologic Cancers: A Meta-analysis.

Dai Y, Yu E, Zeegers M, Wesselius A Adv Nutr. 2023; 15(1):100124.

PMID: 37940476 PMC: 10831898. DOI: 10.1016/j.advnut.2023.09.012.

References

Li M, Bu R . Biological Support to Obesity Paradox in Renal Cell Carcinoma: A Review. Urol Int. 2020; 104(11-12):837-848. DOI: 10.1159/000510245. View

Han M, Jung D, Morel C, Lakhani S, Kim J, Flavell R . JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2012; 339(6116):218-22. PMC: 3835653. DOI: 10.1126/science.1227568. View

Coelho M, Oliveira T, Fernandes R . Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. 2013; 9(2):191-200. PMC: 3648822. DOI: 10.5114/aoms.2013.33181. View

Ito R, Narita S, Huang M, Nara T, Numakura K, Takayama K . The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the "obesity paradox". PLoS One. 2017; 12(2):e0171615. PMC: 5298294. DOI: 10.1371/journal.pone.0171615. View

Bergstrom A, Hsieh C, Lindblad P, Lu C, Cook N, Wolk A . Obesity and renal cell cancer--a quantitative review. Br J Cancer. 2001; 85(7):984-90. PMC: 2375100. DOI: 10.1054/bjoc.2001.2040. View

Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K . Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007; 56(4):901-11. DOI: 10.2337/db06-0911. View

Mendoza-Perez J, Gu J, Herrera L, Tannir N, Zhang S, Matin S . Prognostic significance of promoter CpG island methylation of obesity-related genes in patients with nonmetastatic renal cell carcinoma. Cancer. 2017; 123(18):3617-3627. PMC: 5589484. DOI: 10.1002/cncr.30707. View

Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow G, Norris C, McAlister F . Body mass index and mortality in heart failure: a meta-analysis. Am Heart J. 2008; 156(1):13-22. DOI: 10.1016/j.ahj.2008.02.014. View

Ibrahim Y, Yee D . Insulin-like growth factor-I and cancer risk. Growth Horm IGF Res. 2004; 14(4):261-9. DOI: 10.1016/j.ghir.2004.01.005. View

10.

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

11.

Roberts D, Dive C, Renehan A . Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med. 2009; 61:301-16. DOI: 10.1146/annurev.med.080708.082713. View

12.

Budny A, Grochowski C, Kozlowski P, Kolak A, Kaminska M, Budny B . Obesity as a tumour development triggering factor. Ann Agric Environ Med. 2019; 26(1):13-23. DOI: 10.26444/aaem/100664. View

13.

Lawler H, Underkofler C, Kern P, Erickson C, Bredbeck B, Rasouli N . Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects. J Clin Endocrinol Metab. 2016; 101(4):1422-8. PMC: 4880157. DOI: 10.1210/jc.2015-4125. View

14.

Liu L, Yang Z, Xu Y, Li J, Xu D, Zhang L . Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. PLoS One. 2013; 8(8):e73038. PMC: 3758331. DOI: 10.1371/journal.pone.0073038. View

15.

Klatte T, Seligson D, Riggs S, Leppert J, Berkman M, Kleid M . Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clin Cancer Res. 2007; 13(24):7388-93. DOI: 10.1158/1078-0432.CCR-07-0411. View

16.

Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W . Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Res. 2019; 79(5):954-969. PMC: 6397663. DOI: 10.1158/0008-5472.CAN-18-1790. View

17.

Yaghoubizadeh M, Pishkar L, Basati G . Aberrant Expression of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer and Their Association with Cancer Progression and Prognosis. Gastrointest Tumors. 2020; 7(1-2):11-20. PMC: 7206611. DOI: 10.1159/000503995. View

18.

Pasquali R, Casimirri F, De Iasio R, Mesini P, Boschi S, Chierici R . Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. J Clin Endocrinol Metab. 1995; 80(2):654-8. DOI: 10.1210/jcem.80.2.7852532. View

19.

Turco F, Tucci M, Di Stefano R, Samuelly A, Bungaro M, Audisio M . Renal cell carcinoma (RCC): fatter is better? A review on the role of obesity in RCC. Endocr Relat Cancer. 2021; 28(7):R207-R216. DOI: 10.1530/ERC-20-0457. View

20.

Rose D, Komninou D, Stephenson G . Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev. 2004; 5(3):153-65. DOI: 10.1111/j.1467-789X.2004.00142.x. View