The Association Between Dietary Inflammatory Potential and Urologic Cancers: A Meta-analysis

Overview

Journal Adv Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2023 Nov 8

PMID 37940476

Authors

Ya-Nan Dai

Evan Yi-Wen Yu

Maurice P Zeegers

Anke Wesselius

Affiliations

Soon will be listed here.

Abstract

A meta-analysis published in 2018 indicated a significant association between the dietary inflammatory index (DII) and risk of urologic cancers (UC). The number of included studies was limited, and more research has been published on this topic since then. The current study aimed to find a more precise estimate of the association between dietary inflammatory potential and risk of UC by updating the previous meta-analysis. The PubMed and Embase databases were searched between January 2015 and April 2023 to identify eligible articles. Combined relative risk (RR) and 95% confidence intervals (CI) were calculated by random-effects model to assess the association between dietary inflammatory potential and risk of UC by comparison of the highest versus the lowest category of the DII/empirical dietary inflammatory pattern (EDIP) or by using the continuous DII/EDIP score. The analysis, including 23 studies with 557,576 subjects, showed different results for UC. There was a significant association for prostate cancer among case-control studies (RR = 1.75, 95% CI: 1.34-2.28), whereas among cohort studies a null association was found (RR = 1.02, 95% CI: 0.96-1.08). For bladder cancer, a nonsignificant association was observed in both case-control (RR = 1.59, 95% CI: 0.95-2.64) and cohort studies (RR = 1.03, 95% CI: 0.86-1.24). Pooled RR from 3 case-control studies displayed a statistically significant association between the DII and risk of kidney cancer (RR = 1.27, 95% CI: 1.03-1.56). Although DII was positively associated with all types of UC, no association was found for EDIP. The present meta-analysis confirmed that an inflammatory diet has a direct effect on the development of prostate cancer and kidney cancer. Large-scale studies are needed to demonstrate the association between dietary inflammatory potential and risk of UC and provide effective nutritional advice for UC prevention. PROTOCOL REGISTRATION: The protocol was registered in the International Prospective Register of Systematic Reviews (CRD42023391204).

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References

Shivappa N, Jackson M, Bennett F, Hebert J . Increased Dietary Inflammatory Index (DII) Is Associated With Increased Risk of Prostate Cancer in Jamaican Men. Nutr Cancer. 2015; 67(6):941-8. PMC: 4596719. DOI: 10.1080/01635581.2015.1062117. View

Moradi S, Issah A, Mohammadi H, Mirzaei K . Associations between dietary inflammatory index and incidence of breast and prostate cancer: a systematic review and meta-analysis. Nutrition. 2018; 55-56:168-178. DOI: 10.1016/j.nut.2018.04.018. View

Al-Zalabani A, Stewart K, Wesselius A, Schols A, Zeegers M . Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses. Eur J Epidemiol. 2016; 31(9):811-51. PMC: 5010611. DOI: 10.1007/s10654-016-0138-6. View

Shivappa N, Niclis C, Coquet J, Roman M, Hebert J, Diaz M . Increased inflammatory potential of diet is associated with increased odds of prostate cancer in Argentinian men. Cancer Causes Control. 2018; 29(9):803-813. PMC: 6108929. DOI: 10.1007/s10552-018-1056-6. View

Chow W, Dong L, Devesa S . Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010; 7(5):245-57. PMC: 3012455. DOI: 10.1038/nrurol.2010.46. View

Shivappa N, Bosetti C, Zucchetto A, Montella M, Serraino D, La Vecchia C . Association between dietary inflammatory index and prostate cancer among Italian men. Br J Nutr. 2014; 113(2):278-83. PMC: 4433863. DOI: 10.1017/S0007114514003572. View

Marx W, Veronese N, Kelly J, Smith L, Hockey M, Collins S . The Dietary Inflammatory Index and Human Health: An Umbrella Review of Meta-Analyses of Observational Studies. Adv Nutr. 2021; 12(5):1681-1690. PMC: 8483957. DOI: 10.1093/advances/nmab037. View

Vidal A, Oyekunle T, Howard L, Shivappa N, de Hoedt A, Figueiredo J . Dietary inflammatory index (DII) and risk of prostate cancer in a case-control study among Black and White US Veteran men. Prostate Cancer Prostatic Dis. 2019; 22(4):580-587. PMC: 6790143. DOI: 10.1038/s41391-019-0143-4. View

Perdana N, Mochtar C, Umbas R, Ah Hamid A . The Risk Factors of Prostate Cancer and Its Prevention: A Literature Review. Acta Med Indones. 2016; 48(3):228-238. View

10.

Fu B, Tabung F, Pernar C, Wang W, Gonzalez-Feliciano A, Chowdhury-Paulino I . Insulinemic and Inflammatory Dietary Patterns and Risk of Prostate Cancer. Eur Urol. 2021; 79(3):405-412. PMC: 7887049. DOI: 10.1016/j.eururo.2020.12.030. View

11.

Shivappa N, Hebert J, Askari F, Kardoust Parizi M, Rashidkhani B . Increased Inflammatory Potential of Diet is Associated with Increased Risk of Prostate Cancer in Iranian Men. Int J Vitam Nutr Res. 2017; 86(3-4):161-168. DOI: 10.1024/0300-9831/a000395. View

12.

Catalano M, Roviello G, Santi R, Villari D, Spatafora P, Galli I . Inflammation in Urological Malignancies: The Silent Killer. Int J Mol Sci. 2023; 24(1). PMC: 9821648. DOI: 10.3390/ijms24010866. View

13.

Dianatinasab M, Forozani E, Akbari A, Azmi N, Bastam D, Fararouei M . Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis. BMC Public Health. 2022; 22(1):73. PMC: 8753903. DOI: 10.1186/s12889-022-12516-2. View

14.

Tabung F, Smith-Warner S, Chavarro J, Wu K, Fuchs C, Hu F . Development and Validation of an Empirical Dietary Inflammatory Index. J Nutr. 2016; 146(8):1560-70. PMC: 4958288. DOI: 10.3945/jn.115.228718. View

15.

Shivappa N, Hebert J, Marcos A, Diaz L, Gomez S, Nova E . Association between dietary inflammatory index and inflammatory markers in the HELENA study. Mol Nutr Food Res. 2016; 61(6). PMC: 5517083. DOI: 10.1002/mnfr.201600707. View

16.

McMahon D, Burch J, Hebert J, Hardin J, Zhang J, Wirth M . Diet-related inflammation and risk of prostate cancer in the California Men's Health Study. Ann Epidemiol. 2018; 29:30-38. PMC: 6388401. DOI: 10.1016/j.annepidem.2018.10.008. View

17.

Kustrimovic N, Bombelli R, Baci D, Mortara L . Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment. Int J Mol Sci. 2023; 24(2). PMC: 9860633. DOI: 10.3390/ijms24021511. View

18.

Makino T, Kadomoto S, Izumi K, Mizokami A . Epidemiology and Prevention of Renal Cell Carcinoma. Cancers (Basel). 2022; 14(16). PMC: 9406474. DOI: 10.3390/cancers14164059. View

19.

Wang Y, Shivappa N, Hebert J, Page A, Gill T, Melaku Y . Association between Dietary Inflammatory Index, Dietary Patterns, Plant-Based Dietary Index and the Risk of Obesity. Nutrients. 2021; 13(5). PMC: 8147427. DOI: 10.3390/nu13051536. View

20.

Balduzzi S, Rucker G, Schwarzer G . How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health. 2019; 22(4):153-160. PMC: 10231495. DOI: 10.1136/ebmental-2019-300117. View