Functional Role of MicroRNAs in Regulating Cardiomyocyte Death

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Mar 25

PMID 35326433

Authors

Urna Kansakar

Fahimeh Varzideh

Pasquale Mone

Stanislovas S Jankauskas

Gaetano Santulli

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

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