Mechanisms of Cell Death in Heart Disease

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2012 May 19

PMID 22596221

Citations 178

Authors

Klitos Konstantinidis

Russell S Whelan

Richard N Kitsis

Affiliations

Soon will be listed here.

Abstract

The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a large portion of deaths worldwide. Genetic and pharmacological manipulations indicate that cell death is an important component in the pathogenesis of both diseases. Cells die primarily by apoptosis or necrosis, and autophagy has been associated with cell death. Apoptosis has long been recognized as a highly regulated process. Recent data indicate that a significant subset of necrotic deaths is also programmed. In the review, we discuss the molecular mechanisms that underlie these forms of cell death and their interconnections. The possibility is raised that small molecules aimed at inhibiting cell death may provide novel therapies for these common and lethal heart syndromes.

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