Exosomal CircSCMH1/miR-874 Ratio in Serum to Predict Carotid and Coronary Plaque Stability

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2023 Dec 27

PMID 38149265

Authors

Jiayu Wang

Yixuan Liu

Peiqing Tian

Liyun Xing

Xianwei Huang

Caihua Fu

Xiangyu Xu

Ping Liu

Affiliations

Soon will be listed here.

Abstract

Background: To investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability.

Methods: 701 patients were divided into stable coronary artery disease (SCAD), ACS, and control groups. Furthermore, 225 patients who underwent carotid ultrasound were selected from the above 701 patients and were divided into low-risk plaque, medium-to-high risk plaque, and control (without carotid plaques) groups. We collected their baseline characteristics and measured the contents of exosomal circSCMH1 and miR-874 in peripheral blood. Then lg(circSCMH1/miR-874) was calculated and statistical analysis was performed.

Results: The lg (circSCMH1/miR-874) values of ACS, SCAD, and the control group decreased successively ( < 0.05). Compared with the low-risk plaque and control groups, the lg (circSCMH1/miR-874) value of medium-high risk plaque group decreased ( < 0.05). Multivariate logistic regression analysis showed that with the decrease of lg (circSCMH1/miR-874), the risk of ACS, AMI, and medium-high risk plaques increased. ROC curve analysis demonstrated that lg (circSCMH1/miR-874) has a higher diagnostic value for ACS, AMI and medium-high risk plaques than previously used predictive ratios.

Conclusion: Lg (circSCMH1/miR-874) is closely associated with coronary and carotid plaque stability.

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