Specific Depression Dimensions Are Associated with a Faster Rate of Cognitive Decline in Older Adults

Overview

Journal Alzheimers Dement (Amst)

Date 2022 Mar 23

PMID 35317432

Authors

Laili Soleimani

Michal Schnaider Beeri

Hillel Grossman

Mary Sano

Carolyn W Zhu

Affiliations

Soon will be listed here.

Abstract

Introduction: Understanding the relationship between different depression presentations and cognitive outcome may elucidate high-risk sub-groups for cognitive decline.

Methods: In this study we utilized longitudinal data from the National Alzheimer's Coordinating Center (NACC) on 16,743 initially not demented older adults followed every 12 months for an average of 5 years. Depression dimensions were defined based on the 15-item Geriatric Depression Scale (GDS-15), that is, dysphoric mood, Withdrawal-Apathy-Vigor (WAV), anxiety, hopelessness, and subjective memory complaint (SMC).

Results: After adjustment for sociodemographic and clinical covariates, SMC and hopelessness were associated with faster decline in global cognition and all cognitive domains and WAV with decline executive function. Dysphoric mood and anxiety were not associated with a faster cognitive decline in any of the cognitive domains.

Discussion: Different depression dimensions had different associations with the rate of cognitive decline, suggesting distinct pathophysiology and the need for more targeted interventions.

Citing Articles

Speech markers of depression dimensions across cognitive status.

Soleimani L, Ouyang Y, Cho S, Kia A, Beeri M, Lin H Alzheimers Dement (Amst). 2024; 16(3):e12604.

PMID: 39092182 PMC: 11292393. DOI: 10.1002/dad2.12604.

Network Structure of Depressive Symptomatology in Elderly with Cognitive Impairment.

Pyo J, Lee H, Lee J, Lee D, Yu H, Lim S Medicina (Kaunas). 2024; 60(5).

PMID: 38792870 PMC: 11123453. DOI: 10.3390/medicina60050687.

Specific depression dimensions are associated with a faster rate of cognitive decline in older adults.

Soleimani L, Beeri M, Grossman H, Sano M, Zhu C Alzheimers Dement (Amst). 2022; 14(1):e12268.

PMID: 35317432 PMC: 8923346. DOI: 10.1002/dad2.12268.

References

Starkstein S, Petracca G, Chemerinski E, Kremer J . Syndromic validity of apathy in Alzheimer's disease. Am J Psychiatry. 2001; 158(6):872-7. DOI: 10.1176/appi.ajp.158.6.872. View

Pompili M, Innamorati M, Gonda X, Serafini G, Sarno S, Erbuto D . Affective temperaments and hopelessness as predictors of health and social functioning in mood disorder patients: a prospective follow-up study. J Affect Disord. 2013; 150(2):216-22. DOI: 10.1016/j.jad.2013.03.026. View

Hafkemeijer A, Altmann-Schneider I, Oleksik A, van de Wiel L, Middelkoop H, van Buchem M . Increased functional connectivity and brain atrophy in elderly with subjective memory complaints. Brain Connect. 2013; 3(4):353-62. PMC: 3749691. DOI: 10.1089/brain.2013.0144. View

Mitchell A, Beaumont H, Ferguson D, Yadegarfar M, Stubbs B . Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatr Scand. 2014; 130(6):439-51. DOI: 10.1111/acps.12336. View

Lenehan M, Klekociuk S, Summers M . Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): is it time to abandon subjective memory complaint as an MCI diagnostic criterion?. Int Psychogeriatr. 2012; 24(9):1505-14. DOI: 10.1017/S1041610212000695. View

Mozaffarian D, Benjamin E, Go A, Arnett D, Blaha M, Cushman M . Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation. 2014; 131(4):e29-322. DOI: 10.1161/CIR.0000000000000152. View

Clarke D, Ko J, Lyketsos C, Rebok G, Eaton W . Apathy and cognitive and functional decline in community-dwelling older adults: results from the Baltimore ECA longitudinal study. Int Psychogeriatr. 2010; 22(5):819-29. PMC: 2893259. DOI: 10.1017/S1041610209991402. View

Lyketsos C, Carrillo M, Ryan J, Khachaturian A, Trzepacz P, Amatniek J . Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement. 2011; 7(5):532-9. PMC: 3299979. DOI: 10.1016/j.jalz.2011.05.2410. View

Dotson V, Resnick S, Zonderman A . Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults. Am J Geriatr Psychiatry. 2008; 16(4):318-30. PMC: 2405887. DOI: 10.1097/JGP.0b013e3181662a9c. View

10.

Buch A, Liston C . Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics. Neuropsychopharmacology. 2020; 46(1):156-175. PMC: 7688954. DOI: 10.1038/s41386-020-00789-3. View

11.

Lee J, Suh S, Han J, Byun S, Kwon S, Lee K . Anhedonia and Dysphoria Are Differentially Associated with the Risk of Dementia in the Cognitively Normal Elderly Individuals: A Prospective Cohort Study. Psychiatry Investig. 2019; 16(8):575-580. PMC: 6710416. DOI: 10.30773/pi.2019.06.07. View

12.

Rabin L, Smart C, Amariglio R . Subjective Cognitive Decline in Preclinical Alzheimer's Disease. Annu Rev Clin Psychol. 2017; 13:369-396. DOI: 10.1146/annurev-clinpsy-032816-045136. View

13.

Ruthirakuhan M, Herrmann N, Vieira D, Gallagher D, Lanctot K . The Roles of Apathy and Depression in Predicting Alzheimer Disease: A Longitudinal Analysis in Older Adults With Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2019; 27(8):873-882. PMC: 6646066. DOI: 10.1016/j.jagp.2019.02.003. View

14.

Uher R, Maier W, Hauser J, Marusic A, Schmael C, Mors O . Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry. 2009; 194(3):252-9. DOI: 10.1192/bjp.bp.108.057554. View

15.

Pfeffer R, Kurosaki T, Harrah Jr C, Chance J, Filos S . Measurement of functional activities in older adults in the community. J Gerontol. 1982; 37(3):323-9. DOI: 10.1093/geronj/37.3.323. View

16.

Hidalgo-Mazzei D, Young A, Vieta E, Colom F . Behavioural biomarkers and mobile mental health: a new paradigm. Int J Bipolar Disord. 2018; 6(1):9. PMC: 6161977. DOI: 10.1186/s40345-018-0119-7. View

17.

Monsell S, Dodge H, Zhou X, Bu Y, Besser L, Mock C . Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study. Alzheimer Dis Assoc Disord. 2015; 30(2):134-9. PMC: 4834278. DOI: 10.1097/WAD.0000000000000111. View

18.

Adams K, Matto H, Sanders S . Confirmatory factor analysis of the geriatric depression scale. Gerontologist. 2004; 44(6):818-26. DOI: 10.1093/geront/44.6.818. View

19.

Onyike C, Sheppard J, Tschanz J, Norton M, Green R, Steinberg M . Epidemiology of apathy in older adults: the Cache County Study. Am J Geriatr Psychiatry. 2007; 15(5):365-75. DOI: 10.1097/01.JGP.0000235689.42910.0d. View

20.

Gallagher D, Kiss A, Lanctot K, Herrmann N . Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry. 2018; 26(8):819-827. PMC: 6101977. DOI: 10.1016/j.jagp.2018.05.002. View