Identification of Co-expression Hub Genes for Ferroptosis in Kidney Renal Clear Cell Carcinoma Based on Weighted Gene Co-expression Network Analysis and The Cancer Genome Atlas Clinical Data

Overview

Journal Sci Rep

Specialty Science

Date 2022 Mar 22

PMID 35314744

Authors

Shengxian Li

Ximei Xu

Ruirui Zhang

Yong Huang

Affiliations

Soon will be listed here.

Abstract

Renal clear cell carcinoma (KIRC) is one of the most common tumors worldwide and has a high mortality rate. Ferroptosis is a major mechanism of tumor occurrence and development, as well as important for prognosis and treatment of KIRC. Here, we conducted bioinformatics analysis to identify KIRC hub genes that target ferroptosis. By Weighted gene co-expression network analysis (WGCNA), 11 co-expression-related genes were screened out. According to Kaplan Meier's survival analysis of the data from the gene expression profile interactive analysis database, it was identified that the expression levels of two genes, PROM2 and PLIN2, are respectively related to prognosis. In conclusion, our findings indicate that PROM2 and PLIN2 may be effective new targets for the treatment and prognosis of KIRC.

Citing Articles

Machine Learning Methods for Cancer Classification Using Gene Expression Data: A Review.

Alharbi F, Vakanski A Bioengineering (Basel). 2023; 10(2).

PMID: 36829667 PMC: 9952758. DOI: 10.3390/bioengineering10020173.

Identification and Validation of a Novel Ferroptotic Prognostic Genes-Based Signature of Clear Cell Renal Cell Carcinoma.

Shi Z, Zheng J, Liang Q, Liu Y, Yang Y, Wang R Cancers (Basel). 2022; 14(19).

PMID: 36230613 PMC: 9562262. DOI: 10.3390/cancers14194690.

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