Co-expression Network Analysis Identified Six Hub Genes in Association with Progression and Prognosis in Human Clear Cell Renal Cell Carcinoma (ccRCC)

Overview

Journal Genom Data

Specialty Genetics

Date 2017 Nov 22

PMID 29159069

Citations 52

Authors

Lushun Yuan

Liang Chen

Kaiyu Qian

Guofeng Qian

Chin-Lee Wu

Xinghuan Wang

Yu Xiao

Affiliations

Soon will be listed here.

Abstract

Human clear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney tumors. We constructed a weighted gene co-expression network to identify gene modules associated with clinical features of ccRCC ( = 97). Six hub genes (, , , , and ) were identified in both co-expression and protein-protein interaction (PPI) networks, which were highly correlated with pathologic stage. The significance of expression of the hub genes in ccRCC was ranked top 4 among all cancers and correlated with poor prognosis. Functional analysis revealed that the hub genes were significantly enriched in cell cycle regulation and cell division. Gene set enrichment analysis suggested that the samples with highly expressed hub gene were correlated with cell cycle and p53 signaling pathway. Taken together, six hub genes were identified to be associated with progression and prognosis of ccRCC, and they might lead to poor prognosis by regulating p53 signaling pathway.

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