A Novel Ferroptosis-Related Pathway for Regulating Immune Checkpoints in Clear Cell Renal Cell Carcinoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Aug 9

PMID 34367965

Citations 6

Authors

Su Gao

Hailong Ruan

Jingchong Liu

Yuenan Liu

Di Liu

Junwei Tong

Jian Shi

Hongmei Yang

Tianbo Xu

Xiaoping Zhang

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a novel form of cell death and plays a role in various diseases, especially tumors. It has been reported that ferroptosis is involved in the growth and progression of clear cell renal cell carcinoma (ccRCC); however, the specific molecular mechanisms are still unclear. In this study, we constructed a four-gene signature (FeSig) of ferroptosis-related genes Cox regression analysis. ROC and survival analyses indicated that FeSig had good diagnostic and prognostic value. Further analysis revealed that ferroptosis was associated with tumor immunity in ccRCC. Next, weighted gene co-expression network analysis was performed to identify the potential regulatory mechanisms. Combined with correlation and survival analyses, the TAZ/WNT10B axis was identified as a tumor immune-related regulatory pathway. In conclusion, these findings suggest that ferroptosis is correlated with tumor immunity. The TAZ/WNT10B axis may be a novel biomarker and therapeutic target for immunotherapy in ccRCC.

Citing Articles

Identification and validation of a ferroptosis-related signature for prediction of the prognosis and tumor microenvironment in patients with chromophobe renal cell carcinoma.

Liu S, Yao Y, Hou M, Mei J, Sun L, Zhang G BMC Cancer. 2023; 23(1):1079.

PMID: 37940859 PMC: 10634106. DOI: 10.1186/s12885-023-11589-5.

AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis.

Wang Q, Gao S, Shou Y, Jia Y, Wei Z, Liu Y Int J Biol Sci. 2023; 19(4):1266-1283.

PMID: 36923928 PMC: 10008700. DOI: 10.7150/ijbs.79853.

Identification and Validation of a Novel Ferroptotic Prognostic Genes-Based Signature of Clear Cell Renal Cell Carcinoma.

Shi Z, Zheng J, Liang Q, Liu Y, Yang Y, Wang R Cancers (Basel). 2022; 14(19).

PMID: 36230613 PMC: 9562262. DOI: 10.3390/cancers14194690.

Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis.

Yang J, Zhou Y, Li Y, Hu W, Yuan C, Chen S Bioengineered. 2022; 13(4):11187-11207.

PMID: 35510387 PMC: 9278435. DOI: 10.1080/21655979.2022.2062537.

Dong J, Zhao H, Wang F, Jin J, Ji H, Yan X Front Neurol. 2022; 13:829926.

PMID: 35359663 PMC: 8960280. DOI: 10.3389/fneur.2022.829926.

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