Prevention of the Foreign Body Response to Implantable Medical Devices by Inflammasome Inhibition

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2022 Mar 17

PMID 35298334

Authors

Damiano G Barone

Alejandro Carnicer-Lombarte

Panagiotis Tourlomousis

Russell S Hamilton

Malwina Prater

Alexandra L Rutz

Ivan B Dimov

George G Malliaras

Stephanie P Lacour

Avril A B Robertson

Kristian Franze

James W Fawcett

Clare E Bryant

Affiliations

Soon will be listed here.

Abstract

SignificanceImplantable electronic medical devices (IEMDs) are used for some clinical applications, representing an exciting prospect for the transformative treatment of intractable conditions such Parkinson's disease, deafness, and paralysis. The use of IEMDs is limited at the moment because, over time, a foreign body reaction (FBR) develops at the device-neural interface such that ultimately the IEMD fails and needs to be removed. Here, we show that macrophage nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activity drives the FBR in a nerve injury model yet integration of an NLRP3 inhibitor into the device prevents FBR while allowing full healing of damaged neural tissue to occur.

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