C1q+ Macrophages: Passengers or Drivers of Cancer Progression

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2022 Mar 15

PMID 35288093

Authors

Margot Revel

Catherine Sautes-Fridman

Wolf-Herman Fridman

Lubka T Roumenina

Affiliations

Soon will be listed here.

Abstract

The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood. C1q is co-expressed in healthy and tumor macrophages with human leukocyte antigen DR (HLA-DR), Apolipoprotein E (APOE), and mannose receptor C-type 1 (MRC1) (CD206), suggesting a resident origin of this population. TAM expressing C1q correlate with T cell exhaustion and poor prognosis in numerous cancers. Herein, we discuss the plural roles of C1q in these macrophages and how it could drive cancer progression.

Citing Articles

Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis.

Gao N, Tang H, Li T, Yang Y, Zhao H, Wang L Arthritis Res Ther. 2025; 27(1):55.

PMID: 40065428 PMC: 11892157. DOI: 10.1186/s13075-025-03523-w.

The role of macrophages in liver metastasis: mechanisms and therapeutic prospects.

Yuan Q, Jia L, Yang J, Li W Front Immunol. 2025; 16:1542197.

PMID: 40034694 PMC: 11872939. DOI: 10.3389/fimmu.2025.1542197.

Single-cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis-associated mesothelial cells (EAMCs) and ectopic stromal cells may influence progesterone resistance.

Hou S, Zhang J, Zhang Z, Qu H, Li S, Jiang Y Clin Transl Med. 2025; 15(2):e70216.

PMID: 39968688 PMC: 11836620. DOI: 10.1002/ctm2.70216.

Statistical identification of cell type-specific spatially variable genes in spatial transcriptomics.

Shang L, Wu P, Zhou X Nat Commun. 2025; 16(1):1059.

PMID: 39865128 PMC: 11770176. DOI: 10.1038/s41467-025-56280-4.

Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells.

Zhang Y, Wang X, Gu Y, Liu T, Zhao X, Cheng S Proc Natl Acad Sci U S A. 2025; 122(4):e2420005122.

PMID: 39847320 PMC: 11789090. DOI: 10.1073/pnas.2420005122.