Impact of First COVID-19 Lockdown on Paediatric and Adult Haemophilia Patients Treated in a French Haemophilia Comprehensive Care Centre

Overview

Journal Haemophilia

Specialty Hematology

Date 2022 Mar 3

PMID 35238436

Authors

Fabienne Volot

Agnes Soudry-Faure

Anamaria Callegarin

Elea Ksiazek

Stephanie Delienne

Yves Cottin

Marc Maynadie

Mathieu Boulin

Affiliations

Soon will be listed here.

Abstract

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has created an unprecedented global health crisis.

Aim: To investigate the impact of the 1 COVID-19 lockdown on haemophilia patients in terms of symptoms, management, medication adherence, mental health and lifestyle behaviours.

Methods: A prospective cross-sectional phone survey using a two-part questionnaire was conducted in haemophilia patients (adults and children) followed-up in a French Haemophilia Comprehensive Care Centre between May 5, 2020 and June 2, 2020 (CLEO CD study: NCT04390126).

Results: Among 284 haemophilia A or B patients with FVIII or FIX < 40% contacted for the study, 239 (84%) including 183 adults and 56 children participated to the survey. In 81% of children and 78% of adults, bleeding episodes remained unchanged or decreased. Medication adherence was 82.0% in adults and 98.2% in children. Non-adherence concerned haemostatic agents in six patients and analgesics in three. Overall, 67% of adults and 71% of children felt as good as before lockdown. In both adults and children, the three major changes in lifestyle behaviours were: increase in screen time (49% and 57%), decrease in physical activity (43% and 48%), and weight gain (32% and 27%), respectively.

Conclusions: Encouraging results were observed in terms of haemophilia symptoms, medication adherence, and mental health. Conversely, a negative impact was observed on lifestyle behaviours in a cohort of French haemophilia patients during the 1 lockdown.

Citing Articles

Physical Activity, Bleedings and Quality of Life in Subjects with Haemophilia A without Inhibitors-A Multicenter, Observational Italian Study with a Wearable Device.

Mancuso M, Biasoli C, Marino R, Buzzi A, Preti D, Sannino L J Clin Med. 2024; 13(11).

PMID: 38892747 PMC: 11172795. DOI: 10.3390/jcm13113036.

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis.

Mericliler M, Narayan G Cureus. 2022; 14(10):e30662.

PMID: 36439567 PMC: 9685584. DOI: 10.7759/cureus.30662.

Impact of first COVID-19 lockdown on paediatric and adult haemophilia patients treated in a French Haemophilia Comprehensive Care Centre.

Volot F, Soudry-Faure A, Callegarin A, Ksiazek E, Delienne S, Cottin Y Haemophilia. 2022; 28(3):462-471.

PMID: 35238436 PMC: 9111705. DOI: 10.1111/hae.14526.

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