Recent Advance in Small Molecules Targeting RhlR of  

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 Feb 25

PMID 35203876

Authors

Taehyeong Lim

So-Young Ham

SangJin Nam

Myoungsun Kim

Ki Yong Lee

Hee-Deung Park

Youngjoo Byun

Affiliations

Soon will be listed here.

Abstract

  (. ) is an opportunistic gram-negative pathogen that can cause various infections, particularly in patients with compromised host defenses. . forms biofilms and produces virulence factors through quorum sensing (QS) network, resulting in resistance to antibiotics. RhlI/RhlR, one of key QS systems in . , is considered an attractive target for inhibiting biofilm formation and attenuating virulence factors. Several recent studies examined small molecules targeting the RhlI/RhlR system and their in vitro and in vivo biological activities. In this review, RhlR-targeted modulators, including agonists and antagonists, are discussed with particular focus on structure-activity relationship studies and outlook for next-generation anti-biofilm agents.

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Recent Advance in Small Molecules Targeting RhlR of &nbsp;

Recent Advance in Small Molecules Targeting RhlR of