The Molecular Architecture of Quorum-Sensing Inhibitors

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2022 Aug 25

PMID 36005489

Authors

Qiaoqiang Li

Shen Mao

Hong Wang

Xinyi Ye

Affiliations

Soon will be listed here.

Abstract

The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance. Bacteria gain drug resistance through spontaneous mutation so as to achieve the goals of survival and reproduction. Quorum sensing (QS) is an intercellular communication system based on cell density that can regulate bacterial virulence and biofilm formation. The secretion of more than 30 virulence factors of is controlled by QS, and the formation and diffusion of biofilm is an important mechanism causing the multidrug resistance of , which is also closely related to the QS system. There are three main QS systems in : system, system, and system. Quorum-sensing inhibitors (QSIs) can reduce the toxicity of bacteria without affecting the growth and enhance the sensitivity of bacterial biofilms to antibiotic treatment. These characteristics make QSIs a popular topic for research and development in the field of anti-infection. This paper reviews the research progress of the quorum-sensing system and QSIs, targeting three QS systems, which will provide help for the future research and development of novel quorum-sensing inhibitors.

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