Cell-to-cell Signaling and Pseudomonas Aeruginosa Infections

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 1998 Dec 29

PMID 9866731

Citations 241

Authors

C van Delden

B H Iglewski

Affiliations

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Abstract

Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. Cell-to-cell signaling systems control the expression and allow a coordinated, cell-density-dependent production of many extracellular virulence factors. We discuss the possible role of cell-to-cell signaling in the pathogenesis of P. aeruginosa infections and present a rationale for targeting cell-to-cell signaling systems in the development of new therapeutic approaches.

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