Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2022 Feb 21

PMID 35189037

Authors

Sepehr Talebian

Timothy Schofield

Peter Valtchev

Aaron Schindeler

John M Kavanagh

Qayyum Adil

Fariba Dehghani

Affiliations

Soon will be listed here.

Abstract

The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resistance of probiotics to critical conditions. Owing to the unique properties of biopolymers, they have been prevalently used for microencapsulation of probiotics. However, majority of microencapsulated products only contain a single layer of protection around probiotics, which is likely to be inferior to more sophisticated approaches. This review discusses emerging methods for the multilayer encapsulation of probiotic using biopolymers. Correlations are drawn between fabrication techniques and the resultant microparticle properties. Subsequently, multilayer microparticles are categorized based on their layer designs. Recent reports of specific biopolymeric formulations are examined regarding their physical and biological properties. In particular, animal models of gastrointestinal transit and disease are highlighted, with respect to trials of multilayer microencapsulated probiotics. To conclude, novel materials and approaches for fabrication of multilayer structures are highlighted.

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