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Aaron Schindeler

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Articles 113
Citations 1676
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Recent Articles
1.
ODonohue A, Ginn S, Burgio G, Berman Y, Dabscheck G, Schindeler A
Mol Ther Nucleic Acids . 2025 Mar; 36(1):102475. PMID: 40034205
Neurofibromatosis type 1 (NF1)- and NF2-related schwannomatosis are rare autosomal dominant monogenic disorders characterized by a predisposition for nerve-associated tumors. Current treatments focus on symptomatic management, but advancements in the...
2.
Campbell T, Bennett R, Anderson R, Davey C, ODonohue A, Schindeler A, et al.
JACC Clin Electrophysiol . 2025 Jan; PMID: 39846927
Background: Accurate electroanatomic mapping is critical for identifying scar and the long-term success of ventricular tachycardia ablation. Objectives: This study sought to determine the accuracy of multielectrode mapping (MEM) catheters...
3.
Schofield T, Kavanagh J, Li Z, ODonohue A, Schindeler A, Dehghani F, et al.
ACS Biomater Sci Eng . 2024 Oct; 10(11):6903-6914. PMID: 39370825
Probiotics health benefits are hampered by long-term storage, gastrointestinal transit, and lack of adequate colonization within the colon. To this end, we have designed a core-shell structure that features an...
4.
De Silva K, Campbell T, Bennett R, Anderson R, Davey C, ODonohue A, et al.
Circ Arrhythm Electrophysiol . 2024 Aug; 17(9):e012922. PMID: 39193754
Background: Cardiac magnetic resonance imaging (CMR)-defined ventricular scar and anatomic conduction channels (CMR-CCs) offer promise in delineating ventricular tachycardia substrate. No studies have validated channels with coregistered histology, nor have...
5.
Schindeler A, Ludwig K, Munns C
Clin Endocrinol (Oxf) . 2024 Jul; 101(6):593-601. PMID: 39004952
Hypophosphatasia (HPP) is a rare, inherited, and systemic disorder characterized by impaired skeletal mineralization and low tissue nonspecific serum alkaline phosphatase (TNSALP) activity. It is caused by either autosomal recessive...
6.
ODonohue A, Li X, Lee L, Vasiljevski E, Little D, Munns C, et al.
PLoS One . 2024 Jun; 19(6):e0304778. PMID: 38913608
Neurofibromatosis type 1 (NF1) is a complex genetic disorder that affects a range of tissues including muscle and bone. Recent preclinical and clinical studies have shown that Nf1 deficiency in...
7.
Julovi S, Dao A, Trinh K, ODonohue A, Shu C, Smith S, et al.
RMD Open . 2023 Aug; 9(3). PMID: 37562858
Objective: The prevalence of comorbid chronic kidney disease (CKD) and osteoarthritis (OA) is increasing globally. While sharing common risk factors, the mechanism and consequences of concurrent CKD-OA are unclear. The...
8.
Power H, Valtchev P, Dehghani F, Schindeler A
Aging Cell . 2023 Aug; 22(10):e13948. PMID: 37548098
Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age-related diseases. Since the discovery of the first...
9.
Dao A, ODonohue A, Vasiljevski E, Bobyn J, Little D, Schindeler A
J Bone Jt Infect . 2023 May; 8(2):81-89. PMID: 37123502
: Osteomyelitis remains a major clinical challenge. Many published rodent fracture infection models are costly compared with murine models for rapid screening and proof-of-concept studies. We aimed to develop a...
10.
ODonohue A, Xiao Y, Lee L, Schofield T, Cheng T, Munns C, et al.
Bone . 2022 Dec; 167:116636. PMID: 36462771
Purpose: The creation of murine gene knockout models to study bone gene functions often requires the resource intensive crossbreeding of Cre transgenic and gene-floxed strains. The developmental versus postnatal roles...