Induction of Bdnf from Promoter I Following Electroconvulsive Seizures Contributes to Structural Plasticity in Neurons of the Piriform Cortex

Overview

Journal Brain Stimul

Publisher Elsevier

Specialty Neurology

Date 2022 Feb 20

PMID 35183789

Authors

Anthony D Ramnauth

Kristen R Maynard

Alisha S Kardian

BaDoi N Phan

Madhavi Tippani

Sumita Rajpurohit

John W Hobbs

Stephanie Cerceo Page

Andrew E Jaffe

Keri Martinowich

Affiliations

Soon will be listed here.

Abstract

Background: Electroconvulsive therapy (ECT) efficacy is hypothesized to depend on induction of molecular and cellular events that trigger neuronal plasticity. Investigating how electroconvulsive seizures (ECS) impact plasticity in animal models can help inform our understanding of basic mechanisms by which ECT relieves symptoms of depression. ECS-induced plasticity is associated with differential expression of unique isoforms encoding the neurotrophin, brain-derived neurotrophic factor (BDNF).

Hypothesis: We hypothesized that cells expressing the Bdnf exon 1-containing isoform are important for ECS-induced structural plasticity in the piriform cortex, a highly epileptogenic region that is responsive to ECS.

Methods: We selectively labeled Bdnf exon 1-expressing neurons in mouse piriform cortex using Cre recombinase dependent on GFP technology (CRE-DOG). We then quantified changes in dendrite morphology and density of Bdnf exon 1-expressing neurons.

Results: Loss of promoter I-derived BDNF caused changes in spine density and morphology in Bdnf exon 1-expressing neurons following ECS.

Conclusions: Promoter I-derived Bdnf is required for ECS-induced dendritic structural plasticity in Bdnf exon 1-expressing neurons.

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