Microwave Ablation Via a Flexible Catheter for the Treatment of Nonsurgical Peripheral Lung Cancer: A Pilot Study

Overview

Journal Thorac Cancer

Specialties Oncology
Pulmonary Medicine

Date 2022 Feb 15

PMID 35166043

Authors

Fangfang Xie

Junxiang Chen

Yifeng Jiang

Jiayuan Sun

D Kyle Hogarth

Felix J F Herth

Affiliations

Soon will be listed here.

Abstract

Background: Endobronchial microwave ablation via flexible catheter offers the potential for local therapy for inoperable peripheral lung cancer. The study aimed to evaluate the feasibility and safety of navigation bronchoscopy-guided water-cooled microwave ablation catheter for nonsurgical peripheral lung cancer.

Methods: This was a prospective single arm pilot study. Patients with early stage or multiple primary peripheral lung cancer who were nonsurgical candidates for surgery were enrolled in the study. Bronchoscopic microwave ablation was performed via a flexible water-cooled microwave ablation antenna under the guidance of navigation bronchoscopy. Radial probe endobronchial ultrasound combined with fluoroscopy was used to confirm the position. Treatment outcomes were evaluated based on follow-up chest CT and positron emission tomography scans. Primary endpoints were technical success and safety. Secondary endpoints were complete ablation rate, 2-year local control rate, and progression-free survival.

Results: Thirteen patients were enrolled in the study from April 2018 to July 2019. A total of 19 sessions of microwave ablation were performed on 14 tumors under the guidance of navigation bronchoscopy. The technical success was 100%. Treatment-related complications occurred in two patients. The complete ablation rate was 78.6% (11/14). The 2-year local control rate was 71.4%. Median progression-free survival was 33 months for all patients.

Conclusions: In this pilot study, bronchoscopic microwave ablation appears to be feasible with acceptable occurrence of complication in the treatment of peripheral lung cancer under the guidance of navigation bronchoscopy.

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