Bronchoscopic Ablation of Peripheral Lung Tumors

Overview

Journal J Thorac Dis

Publisher AME Publishing Company

Specialty Pulmonary Medicine

Date 2019 Aug 3

PMID 31372299

Citations 20

Authors

Bruce F Sabath

Roberto F Casal

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the leading cause of cancer-related death worldwide and lobectomy remains the standard of care for patients with early-stage non-small cell lung cancer (NSCLC). The combination of an aging population and the implementation of low-dose CT for lung cancer screening is leading to an increase in diagnosis of early stage NSCLC in medically "inoperable" patients. The recommended treatment for this latter group of patients is stereotactic body radiation therapy (SBRT). However, many patients cannot undergo SBRT because they have received prior radiation or because the tumor is located next to vital structures. Percutaneous ablative therapies have become an alternative to SBRT but, unfortunately, they all violate the pleura and are associated with high rate of pneumothorax. With a more favorable safety profile and the ability to provide also diagnosis and nodal staging, bronchoscopic ablation is hence emerging as a potential future therapeutic alternative for these patients. Herein we review the current state of the art including animal and human data that exists thus far. We also discuss technical and research challenges as well as future directions that this exciting new technology may take.

Citing Articles

Bronchoscopy-Guided High-Power Microwave Ablation in an in vivo Porcine Lung Model.

Sebek J, Goh S, Beard W, Biller D, Hodgson D, Highland M Biomed Hub. 2024; 9(1):108-117.

PMID: 39145138 PMC: 11324231. DOI: 10.1159/000539864.

Transbronchial cryoablation in peripheral lung parenchyma with a novel thin cryoprobe and initial clinical testing.

Gu C, Yuan H, Yang C, Xie F, Chen J, Zhu L Thorax. 2024; 79(7):633-643.

PMID: 38242710 PMC: 11187365. DOI: 10.1136/thorax-2023-220227.

Dual-Layer Spectral CT as Innovative Imaging Guidance in Lung Biopsies: Could Color-Coded Z-Effective Images Allow More Diagnostic Samplings and Biomarkers Information?.

Piacentino F, Fontana F, Zorzetto G, Saccomanno A, Gatta T, Recaldini C J Clin Med. 2023; 12(23).

PMID: 38068478 PMC: 10707312. DOI: 10.3390/jcm12237426.

Mobile Cone-Beam CT-Assisted Bronchoscopy for Peripheral Lung Lesions.

Salahuddin M, Bashour S, Khan A, Chintalapani G, Kleinszig G, Casal R Diagnostics (Basel). 2023; 13(5).

PMID: 36899971 PMC: 10000788. DOI: 10.3390/diagnostics13050827.

Robotic Bronchoscopy: Review of Three Systems.

Diddams M, Lee H Life (Basel). 2023; 13(2).

PMID: 36836710 PMC: 9962823. DOI: 10.3390/life13020354.

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