Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Feb 15

PMID 35163627

Authors

Zhikui Wei

You Chen

Raghu P Upender

Affiliations

Soon will be listed here.

Abstract

Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.

Citing Articles

Association between body roundness index and sleep disorder: the mediating role of depression.

Gong H, Zhao Y BMC Psychiatry. 2025; 25(1):212.

PMID: 40055626 PMC: 11889924. DOI: 10.1186/s12888-025-06664-z.

Sleep duration, daytime napping and the risk of incident metabolic syndrome vary by age and sex: findings from the China health and retirement longitudinal study.

Zhang B, Liu W, Wang J, Zhang L, Wang K, Wang P BMC Public Health. 2025; 25(1):803.

PMID: 40016685 PMC: 11869476. DOI: 10.1186/s12889-025-21915-0.

Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study.

Che L, Zang H, Bi Y, Wen B, Xu L Nat Sci Sleep. 2025; 17:271-284.

PMID: 39936043 PMC: 11812435. DOI: 10.2147/NSS.S497173.

Biomarkers and Seaweed-Based Nutritional Interventions in Metabolic Syndrome: A Comprehensive Review.

Valado A, Cunha M, Pereira L Mar Drugs. 2024; 22(12).

PMID: 39728125 PMC: 11677938. DOI: 10.3390/md22120550.

Translational research in psychiatry.

Chauhan V, Sharma M Ind Psychiatry J. 2024; 33(Suppl 1):S233-S235.

PMID: 39534151 PMC: 11553615. DOI: 10.4103/ipj.ipj_67_24.

References

Benedict C, Shostak A, Lange T, Brooks S, Schioth H, Schultes B . Diurnal rhythm of circulating nicotinamide phosphoribosyltransferase (Nampt/visfatin/PBEF): impact of sleep loss and relation to glucose metabolism. J Clin Endocrinol Metab. 2011; 97(2):E218-22. DOI: 10.1210/jc.2011-2241. View

Hitze B, Bosy-Westphal A, Bielfeldt F, Settler U, Plachta-Danielzik S, Pfeuffer M . Determinants and impact of sleep duration in children and adolescents: data of the Kiel Obesity Prevention Study. Eur J Clin Nutr. 2008; 63(6):739-46. DOI: 10.1038/ejcn.2008.41. View

Azamar-Llamas D, Hernandez-Molina G, Ramos-Avalos B, Furuzawa-Carballeda J . Adipokine Contribution to the Pathogenesis of Osteoarthritis. Mediators Inflamm. 2017; 2017:5468023. PMC: 5401756. DOI: 10.1155/2017/5468023. View

Dahmen N, Manderscheid N, Helfrich J, Musholt P, Forst T, Pfutzner A . Elevated peripheral visfatin levels in narcoleptic patients. PLoS One. 2008; 3(8):e2980. PMC: 2500162. DOI: 10.1371/journal.pone.0002980. View

Mota M, Waterhouse J, De-Souza D, Rossato L, Silva C, Araujo M . Sleep pattern is associated with adipokine levels and nutritional markers in resident physicians. Chronobiol Int. 2014; 31(10):1130-8. DOI: 10.3109/07420528.2014.957300. View

Kotani K, Sakane N, Saiga K, Kato M, Ishida K, Kato Y . Serum adiponectin levels and lifestyle factors in Japanese men. Heart Vessels. 2007; 22(5):291-6. DOI: 10.1007/s00380-006-0969-2. View

Zhuang X, Ni Y, Jiang D, Pu Y, Liu X, Chen S . Vaspin as a Risk Factor of Insulin Resistance in Obstructive Sleep Apnea-Hypopnea Syndrome in an Animal Model. Clin Lab. 2015; 61(8):883-9. DOI: 10.7754/clin.lab.2015.141213. View

Pan Z, Zhuang X, Li X, Huang S, Zhang L, Lou F . Significance of vaspin in obstructive sleep apnea-hypopnea syndrome. Exp Ther Med. 2016; 11(3):841-845. PMC: 4774374. DOI: 10.3892/etm.2016.2997. View

Zhang D, Pang X, Huang R, Gong F, Zhong X, Xiao Y . Adiponectin, Omentin, Ghrelin, and Visfatin Levels in Obese Patients with Severe Obstructive Sleep Apnea. Biomed Res Int. 2018; 2018:3410135. PMC: 6087603. DOI: 10.1155/2018/3410135. View

10.

Hayes A, Xu F, Babineau D, Patel S . Sleep duration and circulating adipokine levels. Sleep. 2011; 34(2):147-52. PMC: 3022933. DOI: 10.1093/sleep/34.2.147. View

11.

Saddi-Rosa P, Oliveira C, Giuffrida F, Reis A . Visfatin, glucose metabolism and vascular disease: a review of evidence. Diabetol Metab Syndr. 2010; 2:21. PMC: 2857825. DOI: 10.1186/1758-5996-2-21. View

12.

Cappuccio F, Miller M . Sleep and Cardio-Metabolic Disease. Curr Cardiol Rep. 2017; 19(11):110. PMC: 5605599. DOI: 10.1007/s11886-017-0916-0. View

13.

Primack C . Obesity and Sleep. Nurs Clin North Am. 2021; 56(4):565-572. DOI: 10.1016/j.cnur.2021.07.012. View

14.

Stern J, Grant A, Thomson C, Tinker L, Hale L, Brennan K . Short sleep duration is associated with decreased serum leptin, increased energy intake and decreased diet quality in postmenopausal women. Obesity (Silver Spring). 2013; 22(5):E55-61. PMC: 4008703. DOI: 10.1002/oby.20683. View

15.

Shapiro S, Chin C, Kirkness J, McGinley B, Patil S, Polotsky V . Leptin and the control of pharyngeal patency during sleep in severe obesity. J Appl Physiol (1985). 2014; 116(10):1334-41. PMC: 4044396. DOI: 10.1152/japplphysiol.00958.2013. View

16.

Hirota T, Morioka T, Yoda K, Toi N, Hayashi N, Maruo S . Positive association of plasma leptin with sleep quality in obese type 2 diabetes patients. J Diabetes Investig. 2018; 9(5):1100-1105. PMC: 6123027. DOI: 10.1111/jdi.12826. View

17.

Lindberg N, Virkkunen M, Tani P, Appelberg B, Rimon R, Porkka-Heiskanen T . Growth hormone-insulin-like growth factor-1 axis, leptin and sleep in anorexia nervosa patients. Neuropsychobiology. 2003; 47(2):78-85. DOI: 10.1159/000070013. View

18.

Wang Q, Feng X, Zhou C, Li P, Kang J . Decreased levels of serum omentin-1 in patients with obstructive sleep apnoea syndrome. Ann Clin Biochem. 2013; 50(Pt 3):230-5. DOI: 10.1177/0004563212473275. View

19.

Omisade A, Buxton O, Rusak B . Impact of acute sleep restriction on cortisol and leptin levels in young women. Physiol Behav. 2010; 99(5):651-6. DOI: 10.1016/j.physbeh.2010.01.028. View

20.

de Mattos A, Pinto M, Oliveira C, Biz C, Ribeiro E, Oller do Nascimento C . Dietary fish oil did not prevent sleep deprived rats from a reduction in adipose tissue adiponectin gene expression. Lipids Health Dis. 2008; 7:43. PMC: 2613381. DOI: 10.1186/1476-511X-7-43. View