Adipokine Contribution to the Pathogenesis of Osteoarthritis

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2017 May 12

PMID 28490838

Citations 68

Authors

Daniel Azamar-Llamas

Gabriela Hernandez-Molina

Barbara Ramos-Avalos

Janette Furuzawa-Carballeda

Affiliations

Soon will be listed here.

Abstract

Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis. Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA. Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA. In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies.

Citing Articles

Zhang Q, Zhao Y, Li L, Fan Q, Huang B, Du H J Inflamm Res. 2025; 18:1207-1233.

PMID: 39886385 PMC: 11780177. DOI: 10.2147/JIR.S499835.

CYR61 as a Potential Apoptosis Biomarker in Osteoarthritis with Comorbidities.

Tokus M, Cicek H, Ates H, Coskun C, Dogus Y, Cicek F J Musculoskelet Neuronal Interact. 2024; 24(4):385-393.

PMID: 39616508 PMC: 11609561.

A Cross-Sectional Study: Systematic Quantification of Chemerin in Human Cerebrospinal Fluid.

Hopfinger A, Behrendt M, Schmid A, Karrasch T, Schaffler A, Berghoff M Biomedicines. 2024; 12(11).

PMID: 39595074 PMC: 11592017. DOI: 10.3390/biomedicines12112508.

Bioactive Compounds in Osteoarthritis: Molecular Mechanisms and Therapeutic Roles.

Maouche A, Boumediene K, Bauge C Int J Mol Sci. 2024; 25(21).

PMID: 39519204 PMC: 11546619. DOI: 10.3390/ijms252111656.

Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities.

Henriques J, Berenbaum F, Mobasheri A Osteoarthr Cartil Open. 2024; 6(4):100511.

PMID: 39483440 PMC: 11525450. DOI: 10.1016/j.ocarto.2024.100511.

References

Junker S, Frommer K, Krumbholz G, Tsiklauri L, Gerstberger R, Rehart S . Expression of adipokines in osteoarthritis osteophytes and their effect on osteoblasts. Matrix Biol. 2016; 62:75-91. DOI: 10.1016/j.matbio.2016.11.005. View

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S . Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002; 8(11):1288-95. DOI: 10.1038/nm788. View

Wang K, Xu J, Cai J, Zheng S, Han W, Antony B . Serum levels of interleukin-17 and adiponectin are associated with infrapatellar fat pad volume and signal intensity alteration in patients with knee osteoarthritis. Arthritis Res Ther. 2016; 18:193. PMC: 5002102. DOI: 10.1186/s13075-016-1088-9. View

Lovren F, Pan Y, Quan A, Szmitko P, Singh K, Shukla P . Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages. Am J Physiol Heart Circ Physiol. 2010; 299(3):H656-63. PMC: 2944489. DOI: 10.1152/ajpheart.00115.2010. View

Koskinen A, Vuolteenaho K, Moilanen T, Moilanen E . Resistin as a factor in osteoarthritis: synovial fluid resistin concentrations correlate positively with interleukin 6 and matrix metalloproteinases MMP-1 and MMP-3. Scand J Rheumatol. 2014; 43(3):249-53. DOI: 10.3109/03009742.2013.853096. View

Berg V, Sveinbjornsson B, Bendiksen S, Brox J, Meknas K, Figenschau Y . Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157). Arthritis Res Ther. 2011; 12(6):R228. PMC: 3046541. DOI: 10.1186/ar3215. View

Zheng S, Xu J, Xu S, Zhang M, Huang S, He F . Association between circulating adipokines, radiographic changes, and knee cartilage volume in patients with knee osteoarthritis. Scand J Rheumatol. 2015; 45(3):224-9. DOI: 10.3109/03009742.2015.1083053. View

Yaykasli K, Hatipoglu O, Yaykasli E, Yildirim K, Kaya E, Ozsahin M . Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-ĸB signaling pathways in human chondrocytes. Cell Biol Int. 2014; 39(1):104-12. DOI: 10.1002/cbin.10336. View

Valcamonica E, Chighizola C, Comi D, De Lucia O, Pisoni L, Murgo A . Levels of chemerin and interleukin 8 in the synovial fluid of patients with inflammatory arthritides and osteoarthritis. Clin Exp Rheumatol. 2014; 32(2):243-50. View

10.

Lee S, Lee H, Kwon Y, Lee S, Cho Y, Kim J . Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes. Cell Metab. 2014; 19(3):484-97. PMC: 3969988. DOI: 10.1016/j.cmet.2014.01.013. View

11.

Oh H, Kwak J, Yang S, Gong M, Kim J, Rhee J . Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD(+)-SIRT axis in articular chondrocytes is involved in osteoarthritis. Osteoarthritis Cartilage. 2015; 23(12):2288-2296. DOI: 10.1016/j.joca.2015.07.009. View

12.

Zhao X, Dong Y, Li D, Hu G, Yao J, Li Y . Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells. Cell Death Dis. 2016; 7:e2188. PMC: 4855655. DOI: 10.1038/cddis.2016.68. View

13.

Richter M, Trzeciak T, Owecki M, Pucher A, Kaczmarczyk J . The role of adipocytokines in the pathogenesis of knee joint osteoarthritis. Int Orthop. 2015; 39(6):1211-7. DOI: 10.1007/s00264-015-2707-9. View

14.

Raucci R, Rusolo F, Sharma A, Colonna G, Castello G, Costantini S . Functional and structural features of adipokine family. Cytokine. 2012; 61(1):1-14. DOI: 10.1016/j.cyto.2012.08.036. View

15.

Francin P, Guillaume C, Humbert A, Pottie P, Netter P, Mainard D . Association between the chondrocyte phenotype and the expression of adipokines and their receptors: evidence for a role of leptin but not adiponectin in the expression of cartilage-specific markers. J Cell Physiol. 2011; 226(11):2790-7. DOI: 10.1002/jcp.22627. View

16.

Tsiotra P, Boutati E, Dimitriadis G, Raptis S . High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed Res Int. 2013; 2013:487081. PMC: 3591160. DOI: 10.1155/2013/487081. View

17.

Chen T, Chen L, Hsieh M, Chang C, Chou D, Tsai S . Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta. 2006; 1762(8):711-8. DOI: 10.1016/j.bbadis.2006.06.008. View

18.

Wittamer V, Franssen J, Vulcano M, Mirjolet J, Le Poul E, Migeotte I . Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med. 2003; 198(7):977-85. PMC: 2194212. DOI: 10.1084/jem.20030382. View

19.

Berry P, Jones S, Cicuttini F, Wluka A, Maciewicz R . Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis. Arthritis Rheum. 2011; 63(3):700-7. DOI: 10.1002/art.30182. View

20.

Sanchez-Margalet V, Martin-Romero C, Gonzalez-Yanes C, Goberna R, Rodriguez-Bano J, Muniain M . Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clin Exp Immunol. 2002; 129(1):119-24. PMC: 1906417. DOI: 10.1046/j.1365-2249.2002.01900.x. View