Ava Handley
Overview
Explore the profile of Ava Handley including associated specialties, affiliations and a list of published articles.
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11
Citations
124
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Recent Articles
1.
Cornell R, Cao W, Harradine B, Godini R, Handley A, Pocock R
Nat Commun
. 2024 Aug;
15(1):6594.
PMID: 39097618
Neurons coordinate inter-tissue protein homeostasis to systemically manage cytotoxic stress. In response to neuronal mitochondrial stress, specific neuronal signals coordinate the systemic mitochondrial unfolded protein response (UPR) to promote organismal...
2.
Moreira P, Papatheodorou P, Deng S, Gopal S, Handley A, Powell D, et al.
Cell Rep
. 2023 Dec;
42(12):113582.
PMID: 38096055
Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting...
3.
Handley A, Wu Q, Sherry T, Cornell R, Pocock R
PLoS Biol
. 2022 May;
20(5):e3001655.
PMID: 35594303
Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. A key part of this network is insulin-like signaling, which is fundamental for surviving glucose...
4.
Baltaci O, Pedersen M, Sherry T, Handley A, Snieckute G, Cao W, et al.
iScience
. 2022 Feb;
25(2):103791.
PMID: 35146399
Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently...
5.
Godini R, Handley A, Pocock R
Front Neurosci
. 2021 Oct;
15:745376.
PMID: 34646119
Behavior encompasses the physical and chemical response to external and internal stimuli. Neurons, each with their own specific molecular identities, act in concert to perceive and relay these stimuli to...
6.
Sherry T, Handley A, Nicholas H, Pocock R
Development
. 2020 Sep;
147(20).
PMID: 32994172
Brain development requires precise regulation of axon outgrowth, guidance and termination by multiple signaling and adhesion molecules. How the expression of these neurodevelopmental regulators is transcriptionally controlled is poorly understood....
7.
Nehammer C, Ejlerskov P, Gopal S, Handley A, Ng L, Moreira P, et al.
Elife
. 2019 Dec;
8.
PMID: 31799933
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival. Here,...
8.
Gorelick S, Buckley G, Gervinskas G, Johnson T, Handley A, Caggiano M, et al.
Elife
. 2019 Jul;
8.
PMID: 31259689
Cryo-electron tomography (cryo-ET) is emerging as a revolutionary method for resolving the structure of macromolecular complexes in situ. However, sample preparation for in situ Cryo-ET is labour-intensive and can require...
9.
Torpe N, Gopal S, Baltaci O, Rella L, Handley A, Korswagen H, et al.
Cell Rep
. 2019 Mar;
26(12):3183-3190.e5.
PMID: 30893592
Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain...
10.
Handley A, Schauer T, Ladurner A, Margulies C
Mol Cell
. 2015 May;
58(4):621-31.
PMID: 26000847
Multicellular organisms depend on cell-type-specific division of labor for survival. Specific cell types have their unique developmental program and respond differently to environmental challenges, yet are orchestrated by the same...