Myelomatous Ascites and Pleural Effusion in Relapsed Multiple Myeloma

Overview

Journal Clin Case Rep

Date 2022 Feb 10

PMID 35140947

Authors

Mizba Baksh

Ke Li

Liuyan Jiang

Victoria Alegria

Taimur Sher

Vivek Roy

Asher Chanan-Khan

Sikander Ailawadhi

Ricardo D Parrondo

Muhamad Alhaj Moustafa

Affiliations

Soon will be listed here.

Abstract

Extramedullary multiple myeloma is seen in advanced and aggressive disease and occurs due to plasma cell infiltration of sites other than the bone marrow. Myelomatous ascites or pleural effusion is seen in less than 1% of cases and can be differentiated from infectious etiologies based on fluid cytology.

Citing Articles

Myelomatous ascites and pleural effusion in relapsed multiple myeloma.

Baksh M, Li K, Jiang L, Alegria V, Sher T, Roy V Clin Case Rep. 2022; 10(2):e05329.

PMID: 35140947 PMC: 8810939. DOI: 10.1002/ccr3.5329.

References

Blade J, Fernandez de Larrea C, Rosinol L, Cibeira M, Jimenez R, Powles R . Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol. 2011; 29(28):3805-12. DOI: 10.1200/JCO.2011.34.9290. View

Mitra S, Mukherjee S, Chakraborty H, Bhattacharyya M . IgG Lambda Myeloma Presenting as Plasmacytic Ascites: Case Report and Review of Literature. Indian J Hematol Blood Transfus. 2015; 31(4):472-9. PMC: 4542761. DOI: 10.1007/s12288-014-0454-5. View

Chen H, Wu T, Li Z, Shen H, Tang J, Fu W . Extramedullary plasmacytoma in the presence of multiple myeloma: clinical correlates and prognostic relevance. Onco Targets Ther. 2012; 5:329-34. PMC: 3496411. DOI: 10.2147/OTT.S35348. View

Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M . Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 2009; 21(2):325-330. DOI: 10.1093/annonc/mdp329. View

Gochhait D, Dey P, Verma N . Cytology of plasma cell rich effusion in cases of plasma cell neoplasm. J Cytol. 2016; 33(3):150-153. PMC: 4995873. DOI: 10.4103/0970-9371.177147. View

Sekiguchi Y, Shirane S, Imai H, Sugimoto K, Wakabayashi M, Sawada T . Response to low-dose bortezomib in plasma cell leukemia patients with malignant pleural effusion and ascites: a case report and a review of the literature. Intern Med. 2012; 51(11):1393-8. DOI: 10.2169/internalmedicine.51.7061. View

Siegel R, Miller K, Fuchs H, Jemal A . Cancer Statistics, 2021. CA Cancer J Clin. 2021; 71(1):7-33. DOI: 10.3322/caac.21654. View

Stoos-Veic T, Ajdukovic R, Jaksic O, Grgurevic I, Tomasovic-Loncaric C, Pejsa V . Myelomatous ascites in patient with liver cirrhosis: A case report. Diagn Cytopathol. 2009; 37(10):780-2. DOI: 10.1002/dc.21156. View

Inoue Y, Chua K, McClure R, Jimenez M, Gocke C, Badros A . Multiple myeloma presenting initially as a solitary pleural effusion later complicated by malignant plasmacytic ascites. Leuk Res. 2005; 29(6):715-8. DOI: 10.1016/j.leukres.2004.12.005. View

10.

Abdulsamad M, Abbas N, Patel H, Balar B, Khaja M . Immunoglobulin A Lambda Multiple Myeloma in a Patient with HIV: An Unusual Cause of Massive Ascites. Case Rep Gastroenterol. 2017; 11(1):201-206. PMC: 5422736. DOI: 10.1159/000468516. View

11.

Birjawi G, Jalbout R, Musallam K, Tawil A, Taher A, Khoury N . Abdominal manifestations of multiple myeloma: a retrospective radiologic overview. Clin Lymphoma Myeloma. 2008; 8(6):348-51. DOI: 10.3816/CLM.2008.n.050. View

12.

Damaj G, Mohty M, Vey N, DIncan E, Bouabdallah R, Faucher C . Features of extramedullary and extraosseous multiple myeloma: a report of 19 patients from a single center. Eur J Haematol. 2004; 73(6):402-6. DOI: 10.1111/j.1600-0609.2004.00331.x. View

13.

Chang H, Chou W, Lee S, Huang J, Hung Y . Myelomatous pleural effusion in a patient with plasmablastic myeloma: a case report. Diagn Cytopathol. 2009; 37(3):205-7. DOI: 10.1002/dc.21004. View

14.

Yokoyama T, Tanaka A, Kato S, Aizawa H . Multiple myeloma presenting initially with pleural effusion and a unique paraspinal tumor in the thorax. Intern Med. 2008; 47(21):1917-20. DOI: 10.2169/internalmedicine.47.1296. View

15.

Ben Ghorbel I, Feki N, Lamloum M, Hamzaoui A, Khanfir M, Ben Salem T . Pleural myelomatous involvement in multiple myeloma: five cases. Ann Saudi Med. 2015; 35(4):327-30. PMC: 6074212. DOI: 10.5144/0256-4947.2015.327. View

16.

Alegre A, Martinez-Chamorro C, Fernandez-Ranada J . Massive myelomatous ascites responsive to VAD chemotherapy and autologous stem cell transplantation. Bone Marrow Transplant. 1999; 24(3):343-4. DOI: 10.1038/sj.bmt.1701892. View

17.

Kumar S, Kimlinger T, Morice W . Immunophenotyping in multiple myeloma and related plasma cell disorders. Best Pract Res Clin Haematol. 2010; 23(3):433-51. PMC: 3005703. DOI: 10.1016/j.beha.2010.09.002. View

18.

Papanikolaou X, Repousis P, Tzenou T, Maltezas D, Kotsopoulou M, Megalakaki K . Incidence, clinical features, laboratory findings and outcome of patients with multiple myeloma presenting with extramedullary relapse. Leuk Lymphoma. 2012; 54(7):1459-64. DOI: 10.3109/10428194.2012.746683. View

19.

Kamble R, Wilson C, Fassas A, Desikan R, Siegel D, Tricot G . Malignant pleural effusion of multiple myeloma: prognostic factors and outcome. Leuk Lymphoma. 2005; 46(8):1137-42. DOI: 10.1080/10428190500102845. View

20.

Ciftciler R, Goker H, Demiroglu H, Aksu S, Sayinalp N, Haznedaroglu I . Evaluation of the Survival Outcomes of Multiple Myeloma Patients According to Their Plasmacytoma Presentation at Diagnosis. Turk J Haematol. 2019; 37(4):256-262. PMC: 7702647. DOI: 10.4274/tjh.galenos.2019.2019.0061. View