Alpha 2.0
Login Register
» Articles » PMID: 27756988

Cytology of Plasma Cell Rich Effusion in Cases of Plasma Cell Neoplasm

Overview
Journal J Cytol
Specialty Cell Biology
Date 2016 Oct 21
PMID 27756988
Citations 3
Authors
Debasis Gochhait
Pranab Dey
Neelam Verma
Affiliations
Soon will be listed here.
Abstract

Background: Multiple myeloma or plasmacytoma resulting in malignant effusion is rarely described in literature.

Aims: In this paper, we have studied the seven rare cases of plasma cell infiltration in effusion fluid.

Materials And Methods: We studied six cases of pleural fluid and one case of ascetic fluid. Detailed cytological features, clinical history, bone marrow examinations, serum electrophoresis, and immunofixation data were analyzed.

Result: There were two cases of plasmacytoma, four cases of multiple myeloma, and one case of plasmablastic lymphoma. On cytology, all the cases showed excess plasma cells along with mesothelial cells and lymphocytes on effusion cytology smear.

Conclusion: Plasma cell rich effusion in cases of plasma cell tumor is rare. However, on cytology these cases do not pose much problem if relevant history is known.

Citing Articles

Plasma Cells Out for a Swim! A Study on Myelomatous Involvement of Effusion Fluid and Cerebrospinal Fluid: A 10-Year Experience from a Tertiary Cancer Center.

De S, Samanta S, Shah M J Cytol. 2025; 42(1):48-53.

PMID: 40078346 PMC: 11896116. DOI: 10.4103/joc.joc_87_24.

CINS: Cell Interaction Network inference from Single cell expression data.

Yuan Y, Cosme Jr C, Adams T, Schupp J, Sakamoto K, Xylourgidis N PLoS Comput Biol. 2022; 18(9):e1010468.

PMID: 36095011 PMC: 9499239. DOI: 10.1371/journal.pcbi.1010468.

Myelomatous ascites and pleural effusion in relapsed multiple myeloma.

Baksh M, Li K, Jiang L, Alegria V, Sher T, Roy V Clin Case Rep. 2022; 10(2):e05329.

PMID: 35140947 PMC: 8810939. DOI: 10.1002/ccr3.5329.

Cell-blocks and hematolymphoid lesions.

Alrajjal A, Choudhury M, Yang J, Gabali A Cytojournal. 2021; 18:7.

PMID: 34221096 PMC: 8248082. DOI: 10.25259/Cytojournal_10_2021.

References
1.
Kim Y, Lee K, Oh H, Park S, Won J, Hong D . Myelomatous effusion with poor response to chemotherapy. J Korean Med Sci. 2000; 15(2):243-6. PMC: 3054621. DOI: 10.3346/jkms.2000.15.2.243. View
2.
Deshpande A, Munshi M . Pleural effusion as an initial manifestation of multiple myeloma. Acta Cytol. 2000; 44(1):103-4. View
3.
OConnell F, Pinkus J, Pinkus G . CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol. 2004; 121(2):254-63. DOI: 10.1309/617D-WB5G-NFWX-HW4L. View
4.
Inoue Y, Chua K, McClure R, Jimenez M, Gocke C, Badros A . Multiple myeloma presenting initially as a solitary pleural effusion later complicated by malignant plasmacytic ascites. Leuk Res. 2005; 29(6):715-8. DOI: 10.1016/j.leukres.2004.12.005. View
5.
Berkman N, Breuer R, Kramer M, Polliack A . Pulmonary involvement in lymphoma. Leuk Lymphoma. 1996; 20(3-4):229-37. DOI: 10.3109/10428199609051612. View