Abdominal Wall Hernia is a Frequent Complication of Polycystic Liver Disease and Associated with Hepatomegaly

Overview

Journal Liver Int

Specialty Gastroenterology

Date 2022 Feb 7

PMID 35129293

Authors

Thijs R M Barten

Roos-Anne M P Bokkerink

Wulphert Venderink

Tom J G Gevers

Richard P G Ten Broek

Joost P H Drenth

Affiliations

Soon will be listed here.

Abstract

Background And Aim: Polycystic liver disease (PLD) is related to hepatomegaly which causes an increased mechanical pressure on the abdominal wall. This may lead to abdominal wall herniation (AWH). We set out to establish the prevalence of AWH in PLD and explore risk factors.

Methods: In this cross-sectional cohort study, we assessed the presence of AWHs from PLD patients with at least 1 abdominal computed tomography or magnetic resonance imaging scan. AWH presence on imaging was independently evaluated by two researchers. Data on potential risk factors were extracted from clinical files.

Results: We included 484 patients of which 40.1% (n = 194) had an AWH. We found a clear predominance of umbilical hernias (25.8%, n = 125) while multiple hernias were present in 6.2% (n = 30). Using multivariate analysis, male sex (odds ratio [OR] 2.727 p < .001), abdominal surgery (OR 2.575, p < .001) and disease severity according to the Gigot classification (Type 3 OR 2.853, p < .001) were identified as risk factors. Height-adjusted total liver volume was an independent PLD-specific risk factor in the subgroup of patients with known total liver volume (OR 1.363, p = .001). Patients with multiple hernias were older (62.1 vs. 55.1, p = .001) and more frequently male (22.0% vs. 50.0%, p = .001).

Conclusion: AWHs occur frequently in PLD with a predominance of umbilical hernias. Hepatomegaly is a clear disease-specific risk factor.

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Abdominal wall hernia is a frequent complication of polycystic liver disease and associated with hepatomegaly.

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