Salmonella Typhimurium Virulence Genes Necessary to Exploit the Itys/s Genotype of the Mouse

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1986 Mar 1

PMID 3512437

Citations 14

Authors

W H Benjamin Jr

C L Turnbough Jr

B S Posey

D E Briles

Affiliations

Soon will be listed here.

Abstract

The studies described in this paper provide evidence that the pathogenesis of Salmonella typhimurium in mice is dependent on interactions between particular genotypes of the infected mice and the infecting Salmonella strain. This conclusion was based on data obtained by infecting a panel of BXD recombinant inbred mice with each of three S. typhimurium strains. One of the S. typhimurium strains was a transconjugant (WB500) produced in an interrupted mating between the two other strains, one (SR-11) of high and the other (LT2-Z) of low virulence for BALB/c mice. We found that strain WB500 appeared to have inherited from SR-11 a gene (or genes) which was required to exploit the Itys/s genotype in mice. However, WB500 apparently lacked other SR-11 virulence gene(s), whose effect on the in vivo growth of SR-11 was independent of the Ity genotype of the mouse.

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References

Sanderson K, Roth J . Linkage map of Salmonella typhimurium, Edition VI. Microbiol Rev. 1983; 47(3):410-53. PMC: 281582. DOI: 10.1128/mr.47.3.410-453.1983. View

OBrien A, Rosenstreich D, SCHER I, Campbell G, Macdermott R, Formal S . Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol. 1980; 124(1):20-4. View

Mackaness G, Blanden R, Collins F . Host-parasite relations in mouse typhoid. J Exp Med. 1966; 124(4):573-83. PMC: 2138243. DOI: 10.1084/jem.124.4.573. View

Lissner C, SWANSON R, OBrien A . Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J Immunol. 1983; 131(6):3006-13. View

Tanaka Y, Katsube Y . Infectivity of Salmonella typhimurium for mice in relation to fimbriae. Nihon Juigaku Zasshi. 1978; 40(6):671-81. DOI: 10.1292/jvms1939.40.671. View

Vogel H, Bonner D . Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem. 1956; 218(1):97-106. View

Milne M, Collins F . Heat-labile antigens of Salmonella enteritidis. I. Extraction of antigens. J Bacteriol. 1966; 92(3):543-8. PMC: 276287. DOI: 10.1128/jb.92.3.543-548.1966. View

Schneider H, Zinder N . Nutrition of the host and natural resistance to infection. V. An improved assay employing genetic markers in the double strain inoculation test. J Exp Med. 1956; 103(2):207-23. PMC: 2136579. DOI: 10.1084/jem.103.2.207. View

Taylor B . Genetic analysis of susceptibility to isoniazid-induced seizures in mice. Genetics. 1976; 83(2):373-7. PMC: 1213520. DOI: 10.1093/genetics/83.2.373. View

10.

OBrien A, Rosenstreich D, Taylor B . Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci. Nature. 1980; 287(5781):440-2. DOI: 10.1038/287440a0. View

11.

DUGUID J . The function of bacterial fimbriae. Arch Immunol Ther Exp (Warsz). 1968; 16(2):173-88. View

12.

Weinstein D, CARSIOTIS M, Lissner C, OBrien A . Flagella help Salmonella typhimurium survive within murine macrophages. Infect Immun. 1984; 46(3):819-25. PMC: 261619. DOI: 10.1128/iai.46.3.819-825.1984. View

13.

Benjamin Jr W, Turnbough Jr C, Posey B, Briles D . The ability of Salmonella typhimurium to produce the siderophore enterobactin is not a virulence factor in mouse typhoid. Infect Immun. 1985; 50(2):392-7. PMC: 261963. DOI: 10.1128/iai.50.2.392-397.1985. View

14.

Eisenstein T, Deakins L, Killar L, Saluk P, SULTZER B . Dissociation of innate susceptibility to Salmonella infection and endotoxin responsiveness in C3HeB/FeJ mice and other strains in the C3H lineage. Infect Immun. 1982; 36(2):696-703. PMC: 351286. DOI: 10.1128/iai.36.2.696-703.1982. View

15.

Plant J, GLYNN A . Locating salmonella resistance gene on mouse chromosome 1. Clin Exp Immunol. 1979; 37(1):1-6. PMC: 1537656. View

16.

Chumley F, Menzel R, Roth J . Hfr formation directed by tn10. Genetics. 1979; 91(4):639-55. PMC: 1216857. DOI: 10.1093/genetics/91.4.639. View

17.

OBrien A, SCHER I, Campbell G, Macdermott R, Formal S . Susceptibility of CBA/N mice to infection with Salmonella typhimurium: influence of the X-linked gene controlling B lymphocyte function. J Immunol. 1979; 123(2):720-4. View

18.

Yancey R, Breeding S, LANKFORD C . Enterochelin (enterobactin): virulence factor for Salmonella typhimurium. Infect Immun. 1979; 24(1):174-80. PMC: 414280. DOI: 10.1128/iai.24.1.174-180.1979. View

19.

Hoiseth S, Stocker B . Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature. 1981; 291(5812):238-9. DOI: 10.1038/291238a0. View

20.

Briles D, Benjamin Jr W, Williams C, Davie J . A genetic locus responsible for salmonella susceptibility in BSVS mice is not responsible for the limited T-dependent immune responsiveness of BSVS mice. J Immunol. 1981; 127(3):906-11. View