The Predicted Amino Acid Sequence of the Salmonella Typhimurium Virulence Gene MviAA(+) Strongly Indicates That MviA is a Regulator Protein of a Previously Unknown S. Typhimurium Response Regulator Family

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1996 Jun 1

PMID 8675354

Citations 7

Authors

W H Benjamin Jr

X Wu

W E Swords

Affiliations

Soon will be listed here.

Abstract

The Salmonella typhimurium virulence gene mviA+ has a predicted amino acid sequence with homology to the N-terminal 112-amino-acid sequence of response regulator proteins. A previously described mutant allele (mviA), which restores virulence to avirulent LT2 strains, was shown to contain a point mutation which would be predicted to cause a single amino acid change, V-102-->G (W. H. Benjamin, Jr., J. Yother, P. Hall, and D. E. Briles, J. Exp. Med. 1,74:1073-1083, 1991). A comparison of the nucleotide sequence of mviA+ with that of the Escherichia coli and Salmonella typhi genes revealed a high degree of conservation.

Citing Articles

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Limited role for the DsrA and RprA regulatory RNAs in rpoS regulation in Salmonella enterica.

Jones A, Goodwill A, Elliott T J Bacteriol. 2006; 188(14):5077-88.

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Fis regulates transcriptional induction of RpoS in Salmonella enterica.

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Role of ppGpp in rpoS stationary-phase regulation in Escherichia coli.

Hirsch M, Elliott T J Bacteriol. 2002; 184(18):5077-87.

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RpoS synthesis is growth rate regulated in Salmonella typhimurium, but its turnover is not dependent on acetyl phosphate synthesis or PTS function.

Cunning C, Elliott T J Bacteriol. 1999; 181(16):4853-62.

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