Bioactive Constituents and Toxicological Evaluation of Selected Antidiabetic Medicinal Plants of Saudi Arabia

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 Jan 27

PMID 35082904

Authors

Ali S Alqahtani

Riaz Ullah

Abdelaaty A Shahat

Affiliations

Soon will be listed here.

Abstract

The purpose of this review is to summarize the available antidiabetic medicinal plants in the Kingdom of Saudi Arabia with its phytoconstituents and toxicological findings supporting by the latest literature. Required data about medicinal plants having antidiabetic activities and growing in the Kingdom of Saudi Arabia were searched/collected from the online databases including Wiley, Google, PubMed, Google Scholar, ScienceDirect, and Scopus. Keywords used in search are in vivo antidiabetic activities, flora of Saudi Arabia, active ingredients, toxicological evaluations, and medicinal plants. A total of 50 plant species belonging to 27 families were found in the flora of Saudi Arabia. Dominant family was found Lamiaceae with 5 species (highest) followed by Moraceae with 4 species. -Amyrin, -sitosterol, stigmasterol, oleanolic acid, ursolic acid, rutin, chlorogenic acid, quercetin, and kaempferol are the very common bioactive constituents of these selected plant species. This paper has presented a list of antidiabetic plants used in the treatment of diabetes mellitus. Bioactive antidiabetic phytoconstituents which showed that these plants have hypoglycemic effects and highly recommended for further pharmacological purposes and to isolate/identify antidiabetes mellitus (anti-DM) active agents also need to investigate the side effects of active ingredients.

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References

Diez R, Garcia J, Diez M, Sierra M, Sahagun A, Fernandez N . Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017; 17(1):298. PMC: 5463324. DOI: 10.1186/s12906-017-1809-x. View

Chen S, Yu H, Luo H, Wu Q, Li C, Steinmetz A . Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med. 2016; 11:37. PMC: 4967523. DOI: 10.1186/s13020-016-0108-7. View

Vutukuri V, Das M, Reddy M, Prabodh S, Sunethri P . Evaluation of Acute Oral Toxicity of Ethanol Leaves Extract of in Wistar Albino Rats. J Clin Diagn Res. 2017; 11(3):FF01-FF04. PMC: 5427331. DOI: 10.7860/JCDR/2017/24937.9325. View

Osman A, Al-Ghamdi F, Bawadekji A . Floristic diversity and vegetation analysis of Wadi Arar: A typical desert Wadi of the Northern Border region of Saudi Arabia. Saudi J Biol Sci. 2014; 21(6):554-65. PMC: 4250517. DOI: 10.1016/j.sjbs.2014.02.001. View

Bahramikia S, Yazdanparast R . Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae). Phytother Res. 2012; 26(11):1581-93. DOI: 10.1002/ptr.4617. View

Goren A, Bilsel G, Bilsel M, Demir H, Kocabas E . Analysis of essential oil of Coridothymus capitatus (L.) and its antibacterial and antifungal activity. Z Naturforsch C J Biosci. 2003; 58(9-10):687-90. DOI: 10.1515/znc-2003-9-1016. View

Jain N, Singhai A . Protective role of Beta vulgaris L. leaves extract and fractions on ethanol-mediated hepatic toxicity. Acta Pol Pharm. 2012; 69(5):945-50. View

Omotoso K, Aigbe F, Salako O, Chijioke M, Adeyemi O . Toxicological evaluation of the aqueous whole plant extract of Aerva lanata (l.) Juss. ex Schult (Amaranthaceae). J Ethnopharmacol. 2017; 208:174-184. DOI: 10.1016/j.jep.2017.06.032. View

Ruckmani A, Meti V, Vijayashree R, Arunkumar R, Konda V, Prabhu L . Anti-rheumatoid activity of ethanolic extract of seed extract in Freund's complete adjuvant induced arthritis in Wistar albino rats. J Tradit Complement Med. 2018; 8(3):377-386. PMC: 6035311. DOI: 10.1016/j.jtcme.2017.06.003. View

10.

Awaad A, Alkanhal H, El-Meligy R, Zain G, Sesh Adri V, Hassan D . Anti-ulcerative colitis activity of Linn. Saudi Pharm J. 2018; 26(1):75-78. PMC: 5783809. DOI: 10.1016/j.jsps.2017.10.010. View

11.

Kaunda J, Zhang Y . The Genus Carissa: An Ethnopharmacological, Phytochemical and Pharmacological Review. Nat Prod Bioprospect. 2017; 7(2):181-199. PMC: 5397391. DOI: 10.1007/s13659-017-0123-0. View

12.

Shahat A, Ullah R, Alqahtani A, AlSaid M, Husseiny H, Al Meanazel O . Hepatoprotective Effect of Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats. Evid Based Complement Alternat Med. 2019; 2018:3782768. PMC: 6311294. DOI: 10.1155/2018/3782768. View

13.

Manach C, Scalbert A, Morand C, Remesy C, Jimenez L . Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004; 79(5):727-47. DOI: 10.1093/ajcn/79.5.727. View

14.

Allahyari S, Delazar A, Najafi M . Evaluation of general toxicity, anti-oxidant activity and effects of ficus carica leaves extract on ischemia/reperfusion injuries in isolated heart of rat. Adv Pharm Bull. 2015; 4(Suppl 2):577-82. PMC: 4312408. DOI: 10.5681/apb.2014.085. View

15.

Mohd Azman N, Gallego M, Segovia F, Abdullah S, Shaarani S, Almajano Pablos M . Study of the Properties of Bearberry Leaf Extract as a Natural Antioxidant in Model Foods. Antioxidants (Basel). 2016; 5(2). PMC: 4931532. DOI: 10.3390/antiox5020011. View

16.

Taj Eldin I, Ahmed E, Elwahab H M A . Preliminary Study of the Clinical Hypoglycemic Effects of Allium cepa (Red Onion) in Type 1 and Type 2 Diabetic Patients. Environ Health Insights. 2010; 4:71-7. PMC: 2978938. DOI: 10.4137/EHI.S5540. View

17.

Ibrahim S, Abdallah H, Mohamed G, Farag M, Alshali K, Alsherif E . Volatile oil profile of some lamiaceous plants growing in Saudi Arabia and their biological activities. Z Naturforsch C J Biosci. 2016; 72(1-2):35-41. DOI: 10.1515/znc-2015-0234. View

18.

Wang F, Li H, Zhao H, Zhang Y, Qiu P, Li J . Antidiabetic Activity and Chemical Composition of Melon Seed Oil. Evid Based Complement Alternat Med. 2018; 2018:5434156. PMC: 5954909. DOI: 10.1155/2018/5434156. View

19.

Moufid A, Eddouks M . Artemisia herba alba: a popular plant with potential medicinal properties. Pak J Biol Sci. 2013; 15(24):1152-9. DOI: 10.3923/pjbs.2012.1152.1159. View

20.

Azaizeh H, Fulder S, Khalil K, Said O . Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern region. Fitoterapia. 2003; 74(1-2):98-108. DOI: 10.1016/s0367-326x(02)00285-x. View