Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Jan 21

PMID 35053446

Authors

Valerie Jacquemin

Mathieu Antoine

Genevieve Dom

Vincent Detours

Carine Maenhaut

Jacques E Dumont

Affiliations

Soon will be listed here.

Abstract

Though heterogeneity of cancers is recognized and has been much discussed in recent years, the concept often remains overlooked in different routine examinations. Indeed, in clinical or biological articles, reviews, and textbooks, cancers and cancer cells are generally presented as evolving distinct entities rather than as an independent heterogeneous cooperative cell population with its self-oriented biology. There are, therefore, conceptual gaps which can mislead the interpretations/diagnostic and therapeutic approaches. In this short review, we wish to summarize and discuss various aspects of this dynamic evolving heterogeneity and its biological, pathological, clinical, diagnostic, and therapeutic implications, using thyroid carcinoma as an illustrative example.

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