Recent Development of Probiotic for Treating Human Diseases

Overview

Journal Front Bioeng Biotechnol

Date 2022 Jan 10

PMID 35004640

Authors

Jun Chen

Xinyi Chen

Chun Loong Ho

Affiliations

Soon will be listed here.

Abstract

is a non-spore-forming, Gram-positive, anaerobic probiotic actinobacterium and commonly found in the gut of infants and the uterine region of pregnant mothers. Like all probiotics, confer health benefits on the host when administered in adequate amounts, showing multifaceted probiotic effects. Examples include and , common strains employed to prevent and treat gastrointestinal disorders, including intestinal infections and cancers. Herein, we review the latest development in probiotic research, including studies on the therapeutic impact of species on human health and recent efforts in engineering . This review article would provide readers with a wholesome understanding of and its potentials to improve human health.

Citing Articles

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.

Gualtieri P, Frank G, Cianci R, Ciancarella L, Romano L, Ortoman M Nutrients. 2025; 17(5).

PMID: 40077790 PMC: 11901643. DOI: 10.3390/nu17050922.

Glucagon-Like Peptide 1 Receptor () Deficiency Does Not Appreciably Alter Airway Inflammation or Gut-Lung Microbiome Axis in a Mouse Model of Obese Allergic Airways Disease and Bariatric Surgery.

Kim Y, Ihrie V, Shi P, Ihrie M, Womble J, Meares A J Asthma Allergy. 2025; 18:285-305.

PMID: 40046174 PMC: 11880686. DOI: 10.2147/JAA.S478329.

Gut Microbial Signatures Associated with Cryptosporidiosis: A Case Series.

Piazzesi A, Pane S, Romani L, Toto F, Scanu M, Marsiglia R Microorganisms. 2025; 13(2).

PMID: 40005709 PMC: 11858469. DOI: 10.3390/microorganisms13020342.

The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies.

Kaltsas A, Giannakodimos I, Markou E, Adamos K, Stavropoulos M, Kratiras Z Microorganisms. 2025; 13(2).

PMID: 40005617 PMC: 11857656. DOI: 10.3390/microorganisms13020250.

Effects of Vegetable and Fruit Juicing on Gut and Oral Microbiome Composition.

Sardaro M, Grote V, Baik J, Atallah M, Amato K, Ring M Nutrients. 2025; 17(3).

PMID: 39940316 PMC: 11820471. DOI: 10.3390/nu17030458.

References

Brown C, Mtui D, Oswald B, Van Leuven J, Vallender E, Schultz-Darken N . Comparative genomics of Bifidobacterium species isolated from marmosets and humans. Am J Primatol. 2019; 81(10-11):e983. PMC: 6900142. DOI: 10.1002/ajp.22983. View

Takeuchi A, Matsumura H, Kano Y . Cloning and expression in Escherichia coli of a gene, hup, encoding the histone-like protein HU of Bifidobacterium longum. Biosci Biotechnol Biochem. 2002; 66(3):598-603. DOI: 10.1271/bbb.66.598. View

Landete J, Peiroten A, Rodriguez E, Margolles A, Medina M, Arques J . Anaerobic green fluorescent protein as a marker of Bifidobacterium strains. Int J Food Microbiol. 2014; 175:6-13. DOI: 10.1016/j.ijfoodmicro.2014.01.008. View

Zu C, Wang J . Tumor-colonizing bacteria: a potential tumor targeting therapy. Crit Rev Microbiol. 2013; 40(3):225-35. DOI: 10.3109/1040841X.2013.776511. View

Guglielmetti S, Mora D, Gschwender M, Popp K . Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011; 33(10):1123-32. DOI: 10.1111/j.1365-2036.2011.04633.x. View

Tian P, ORiordan K, Lee Y, Wang G, Zhao J, Zhang H . Towards a psychobiotic therapy for depression: CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiol Stress. 2020; 12:100216. PMC: 7109524. DOI: 10.1016/j.ynstr.2020.100216. View

Nguyen M, Holdbrooks H, Mishra P, Abrantes M, Eskew S, Garma M . Impact of Probiotic EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation. Front Pediatr. 2021; 9:618009. PMC: 7921802. DOI: 10.3389/fped.2021.618009. View

Vieira A, Rocha V, Tavares L, Garcia C, Teixeira M, Oliveira S . Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5(1A). Microbes Infect. 2015; 18(3):180-9. DOI: 10.1016/j.micinf.2015.10.008. View

Jang H, Lee K, Kim D . The Preventive and Curative Effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on Immobilization Stress-Induced Anxiety/Depression and Colitis in Mice. Nutrients. 2019; 11(4). PMC: 6521032. DOI: 10.3390/nu11040819. View

10.

Kanesaki Y, Masutani H, Sakanaka M, Shiwa Y, Fujisawa T, Nakamura Y . Complete Genome Sequence of Bifidobacterium longum 105-A, a Strain with High Transformation Efficiency. Genome Announc. 2014; 2(6). PMC: 4271160. DOI: 10.1128/genomeA.01311-14. View

11.

Sheu B, Cheng H, Kao A, Wang S, Yang Y, Yang H . Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr. 2006; 83(4):864-9. DOI: 10.1093/ajcn/83.4.864. View

12.

Watson D, Sleator R, Hill C, Gahan C . Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract. BMC Microbiol. 2008; 8:176. PMC: 2577680. DOI: 10.1186/1471-2180-8-176. View

13.

Kazemi A, Noorbala A, Azam K, Eskandari M, Djafarian K . Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin Nutr. 2018; 38(2):522-528. DOI: 10.1016/j.clnu.2018.04.010. View

14.

Tan R, Dong H, Chen Z, Jin M, Yin J, Li H . Intestinal Microbiota Mediates High-Fructose and High-Fat Diets to Induce Chronic Intestinal Inflammation. Front Cell Infect Microbiol. 2021; 11:654074. PMC: 8242949. DOI: 10.3389/fcimb.2021.654074. View

15.

Arunachalam K, Gill H, Chandra R . Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr. 2000; 54(3):263-7. DOI: 10.1038/sj.ejcn.1600938. View

16.

Coakley M, Ross R, Nordgren M, Fitzgerald G, Devery R, Stanton C . Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species. J Appl Microbiol. 2002; 94(1):138-45. DOI: 10.1046/j.1365-2672.2003.01814.x. View

17.

Ricoldi M, Furlaneto F, Oliveira L, Teixeira G, Pischiotini J, Moreira A . Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats. PLoS One. 2017; 12(6):e0179946. PMC: 5491108. DOI: 10.1371/journal.pone.0179946. View

18.

Raimondi S, Amaretti A, Leonardi A, Quartieri A, Gozzoli C, Rossi M . Conjugated Linoleic Acid Production by Bifidobacteria: Screening, Kinetic, and Composition. Biomed Res Int. 2016; 2016:8654317. PMC: 4939342. DOI: 10.1155/2016/8654317. View

19.

Finamore A, Roselli M, Donini L, Brasili D, Rami R, Carnevali P . Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice. Nutrition. 2019; 63-64:184-192. DOI: 10.1016/j.nut.2019.02.005. View

20.

Hong K, Kang H, Im J, Ji G, Kim S, Jung H . Effect of probiotics on symptoms in korean adults with irritable bowel syndrome. Gut Liver. 2010; 3(2):101-7. PMC: 2852694. DOI: 10.5009/gnl.2009.3.2.101. View