Next-Generation Probiotics and Chronic Diseases: A Review of Current Research and Future Directions

Overview

Journal J Agric Food Chem

Specialties Chemistry
Nutritional Sciences

Date 2024 Nov 26

PMID 39588716

Authors

Ashutosh Tiwari

Dyah Ika Krisnawati

Erna Susilowati

Chinmaya Mutalik

Tsung-Rong Kuo

Affiliations

Soon will be listed here.

Abstract

The burgeoning field of microbiome research has profoundly reshaped our comprehension of human health, particularly highlighting the potential of probiotics and fecal microbiota transplantation (FMT) as therapeutic interventions. While the benefits of traditional probiotics are well-recognized, the efficacy and mechanisms remain ambiguous, and FMT's long-term effects are still being investigated. Recent advancements in high-throughput sequencing have identified gut microbes with significant health benefits, paving the way for next-generation probiotics (NGPs). These NGPs, engineered through synthetic biology and bioinformatics, are designed to address specific disease states with enhanced stability and viability. This review synthesizes current research on NGP stability, challenges in delivery, and their applications in preventing and treating chronic diseases such as diabetes, obesity, and cardiovascular diseases. We explore the physiological characteristics, safety profiles, and mechanisms of action of various NGP strains while also addressing the challenges and opportunities presented by their integration into clinical practice. The potential of NGPs to revolutionize microbiome-based therapies and improve clinical outcomes is immense, underscoring the need for further research to optimize their efficacy and ensure their safety.

References

Nazir Y, Hussain S, Hamid A, Song Y . Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases. Biomed Res Int. 2018; 2018:3428437. PMC: 6136537. DOI: 10.1155/2018/3428437. View

Cleusix V, Lacroix C, Vollenweider S, Duboux M, Le Blay G . Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria. BMC Microbiol. 2007; 7:101. PMC: 2222629. DOI: 10.1186/1471-2180-7-101. View

Ridaura V, Faith J, Rey F, Cheng J, Duncan A, Kau A . Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013; 341(6150):1241214. PMC: 3829625. DOI: 10.1126/science.1241214. View

Dan T, Jin R, Ren W, Li T, Chen H, Sun T . Characteristics of Milk Fermented by Streptococcus thermophilus MGA45-4 and the Profiles of Associated Volatile Compounds during Fermentation and Storage. Molecules. 2018; 23(4). PMC: 6017517. DOI: 10.3390/molecules23040878. View

Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L . A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 2016; 23(1):107-113. DOI: 10.1038/nm.4236. View

Olier M, Marcq I, Salvador-Cartier C, Secher T, Dobrindt U, Boury M . Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity. Gut Microbes. 2012; 3(6):501-9. PMC: 3495787. DOI: 10.4161/gmic.21737. View

Hidalgo-Cantabrana C, OFlaherty S, Barrangou R . CRISPR-based engineering of next-generation lactic acid bacteria. Curr Opin Microbiol. 2017; 37:79-87. DOI: 10.1016/j.mib.2017.05.015. View

Buffington S, Di Prisco G, Auchtung T, Ajami N, Petrosino J, Costa-Mattioli M . Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell. 2016; 165(7):1762-1775. PMC: 5102250. DOI: 10.1016/j.cell.2016.06.001. View

Pompei A, Cordisco L, Amaretti A, Zanoni S, Matteuzzi D, Rossi M . Folate production by bifidobacteria as a potential probiotic property. Appl Environ Microbiol. 2006; 73(1):179-85. PMC: 1797147. DOI: 10.1128/AEM.01763-06. View

10.

Chiu L, Bazin T, Truchetet M, Schaeverbeke T, Delhaes L, Pradeu T . Protective Microbiota: From Localized to Long-Reaching Co-Immunity. Front Immunol. 2017; 8:1678. PMC: 5725472. DOI: 10.3389/fimmu.2017.01678. View

11.

Mousavinasab F, Karimi R, Taheri S, Ahmadvand F, Sanaaee S, Najafi S . Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering. Cancer Cell Int. 2023; 23(1):271. PMC: 10640760. DOI: 10.1186/s12935-023-03095-2. View

12.

Chambers E, Preston T, Frost G, Morrison D . Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep. 2018; 7(4):198-206. PMC: 6244749. DOI: 10.1007/s13668-018-0248-8. View

13.

Cani P, de Vos W . Next-Generation Beneficial Microbes: The Case of . Front Microbiol. 2017; 8:1765. PMC: 5614963. DOI: 10.3389/fmicb.2017.01765. View

14.

Gao H, Li X, Chen X, Hai D, Wei C, Zhang L . The Functional Roles of in Different Physiological and Pathological Processes. J Microbiol Biotechnol. 2022; 32(10):1226-1233. PMC: 9668099. DOI: 10.4014/jmb.2205.05041. View

15.

Li P, Roos S, Luo H, Ji B, Nielsen J . Metabolic engineering of human gut microbiome: Recent developments and future perspectives. Metab Eng. 2023; 79:1-13. DOI: 10.1016/j.ymben.2023.06.006. View

16.

Zmora N, Suez J, Elinav E . You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2018; 16(1):35-56. DOI: 10.1038/s41575-018-0061-2. View

17.

Jiang C, Wang H, Xia C, Dong Q, Chen E, Qiu Y . A randomized, double-blind, placebo-controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma. Cancer. 2018; 125(7):1081-1090. DOI: 10.1002/cncr.31907. View

18.

Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S . Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019; 25(7):1096-1103. PMC: 6699990. DOI: 10.1038/s41591-019-0495-2. View

19.

Park S, Kang S, Kim S, Kim T, Cha J, Im J . Additive effect of probiotics (Mutaflor) on 5-aminosalicylic acid therapy in patients with ulcerative colitis. Korean J Intern Med. 2022; 37(5):949-957. PMC: 9449212. DOI: 10.3904/kjim.2021.458. View

20.

Zhang H, Duan Y, Cai F, Cao D, Wang L, Qiao Z . Next-Generation Probiotics: Microflora Intervention to Human Diseases. Biomed Res Int. 2022; 2022:5633403. PMC: 9683952. DOI: 10.1155/2022/5633403. View