Purinergic Receptors Mediate Endothelial Dysfunction and Participate in Atherosclerosis

Overview

Journal Purinergic Signal

Publisher Springer

Date 2022 Jan 4

PMID 34981330

Citations 11

Authors

Xian-Ming Wu

Ning Zhang

Jiang-Shan Li

Zhi-Hong Yang

Xiao-Lou Huang

Xiao-Fang Yang

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is the main pathological basis of cardiovascular disease and involves damage to vascular endothelial cells (ECs) that results in endothelial dysfunction (ED). The vascular endothelium is the key to maintaining blood vessel health and homeostasis. ED is a complex pathological process involving inflammation, shear stress, vascular tone, adhesion of leukocytes to ECs, and platelet aggregation. The activation of P2X4, P2X7, and P2Y2 receptors regulates vascular tone in response to shear stress, while activation of the A2A, P2X4, P2X7, P2Y1, P2Y2, P2Y6, and P2Y12 receptors promotes the secretion of inflammatory cytokines. Finally, P2X1, P2Y1, and P2Y12 receptor activation regulates platelet activity. These purinergic receptors mediate ED and participate in atherosclerosis. In short, P2X4, P2X7, P2Y1, and P2Y12 receptors are potential therapeutic targets for atherosclerosis.

Citing Articles

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