» Articles » PMID: 38396639

Photodynamic Therapy for Atherosclerosis

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2024 Feb 24
PMID 38396639
Authors
Affiliations
Soon will be listed here.
Abstract

Atherosclerosis, which currently contributes to 31% of deaths globally, is of critical cardiovascular concern. Current diagnostic tools and biomarkers are limited, emphasizing the need for early detection. Lifestyle modifications and medications form the basis of treatment, and emerging therapies such as photodynamic therapy are being developed. Photodynamic therapy involves a photosensitizer selectively targeting components of atherosclerotic plaques. When activated by specific light wavelengths, it induces localized oxidative stress aiming to stabilize plaques and reduce inflammation. The key advantage lies in its selective targeting, sparing healthy tissues. While preclinical studies are encouraging, ongoing research and clinical trials are crucial for optimizing protocols and ensuring long-term safety and efficacy. The potential combination with other therapies makes photodynamic therapy a versatile and promising avenue for addressing atherosclerosis and associated cardiovascular disease. The investigations underscore the possibility of utilizing photodynamic therapy as a valuable treatment choice for atherosclerosis. As advancements in research continue, photodynamic therapy might become more seamlessly incorporated into clinical approaches for managing atherosclerosis, providing a blend of efficacy and limited invasiveness.

Citing Articles

Enhancing the Photocatalytic Efficacy of g-CN Through Irradiation Modification and Composite Construction with TiC for Photodynamic Therapy.

Huang B, Wang Y, Chen X, Wu Y, Xu K, Xie S Molecules. 2025; 30(3).

PMID: 39942591 PMC: 11820621. DOI: 10.3390/molecules30030487.


Photodynamic Therapy for Atherosclerosis: Past, Present, and Future.

Lin Y, Xie R, Yu T Pharmaceutics. 2024; 16(6).

PMID: 38931851 PMC: 11206729. DOI: 10.3390/pharmaceutics16060729.

References
1.
Martindale J, Holbrook N . Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002; 192(1):1-15. DOI: 10.1002/jcp.10119. View

2.
Quyyumi A, Tahhan A . High-Sensitivity Troponin and Coronary Artery Disease Severity: A Bridge Too Far?. JACC Cardiovasc Imaging. 2018; 12(6):1056-1057. DOI: 10.1016/j.jcmg.2018.03.028. View

3.
Prilepskii A, Serov N, Kladko D, Vinogradov V . Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis. Pharmaceutics. 2020; 12(11). PMC: 7694323. DOI: 10.3390/pharmaceutics12111056. View

4.
Woodburn K, Fan Q, Kessel D, Wright M, Mody T, Hemmi G . Phototherapy of cancer and atheromatous plaque with texaphyrins. J Clin Laser Med Surg. 1996; 14(5):343-8. DOI: 10.1089/clm.1996.14.343. View

5.
Zarkasi K, Abdullah N, Abdul Murad N, Ahmad N, Jamal R . Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies. Diagnostics (Basel). 2022; 12(10). PMC: 9601486. DOI: 10.3390/diagnostics12102561. View