Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

Overview

Journal Science

Specialty Science

Date 1987 Jan 16

PMID 3492043

Citations 33

Authors

D F Stern

D L Hare

M A Cecchini

R A Weinberg

Affiliations

Soon will be listed here.

Abstract

The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.

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