Cardiometabolic Health Benefits of Dairy-milk Polar Lipids

Overview

Journal Nutr Rev

Publisher Oxford University Press

Specialty Nutritional Sciences

Date 2021 Dec 8

PMID 34879146

Citations 11

Authors

Richard S Bruno

Avinash Pokala

Moises Torres-Gonzalez

Christopher N Blesso

Affiliations

Soon will be listed here.

Abstract

Low-quality dietary patterns impair cardiometabolic health by increasing the risk of obesity-related disorders. Cardiometabolic risk relative to dairy-food consumption continues to be a controversial topic, due to recommendations that endorse low-fat and nonfat dairy foods over full-fat varieties despite accumulated evidence that does not strongly support these recommendations. Controlled human studies and mechanistic preclinical investigations support that full-fat dairy foods decrease cardiometabolic risk by promoting gut health, reducing inflammation, and managing dyslipidemia. These gut- and systemic-level cardiometabolic benefits are attributed, at least in part, to milk polar lipids (MPLs) derived from the phospholipid- and sphingolipid-rich milk fat globule membrane that is of higher abundance in full-fat dairy milk. The controversy surrounding full-fat dairy food consumption is discussed in this review relative to cardiometabolic health and MPL bioactivities that alleviate dyslipidemia, shift gut microbiota composition, and reduce inflammation. This summary, therefore, is expected to advance the understanding of full-fat dairy foods through their MPLs and the need for translational research to establish evidence-based dietary recommendations.

Citing Articles

A global analysis of dairy consumption and incident cardiovascular disease.

Zhuang P, Liu X, Li Y, Ao Y, Wu Y, Ye H Nat Commun. 2025; 16(1):437.

PMID: 39762253 PMC: 11704150. DOI: 10.1038/s41467-024-55585-0.

Full-fat dairy products and cardiometabolic health outcomes: Does the dairy-fat matrix matter?.

Taormina V, Unger A, Kraft J Front Nutr. 2024; 11:1386257.

PMID: 39135556 PMC: 11317386. DOI: 10.3389/fnut.2024.1386257.

Polar lipids modify Alzheimer's Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation.

Hans S, Stanton J, Sauer A, Shiels K, Saha S, Lordan R Lipids Health Dis. 2024; 23(1):113.

PMID: 38643113 PMC: 11031880. DOI: 10.1186/s12944-024-02106-z.

Bioactive Functions of Lipids in the Milk Fat Globule Membrane: A Comprehensive Review.

Pan J, Chen M, Li N, Han R, Yang Y, Zheng N Foods. 2023; 12(20).

PMID: 37893646 PMC: 10606317. DOI: 10.3390/foods12203755.

The Role of Lipids in the Regulation of Immune Responses.

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