Prognostic Death Factors in Secondary Hemophagocytic Lymphohistiocytosis Children with Multiple Organ Dysfunction Syndrome Receiving Continuous Renal Replacement Therapy: A Multicenter Prospective Nested Case-control Study

Overview

Journal Ther Apher Dial

Date 2021 Dec 8

PMID 34877787

Citations 3

Authors

Yun Cui

Jingyi Shi

Guoping Lu

Ying Wang

Xiaodong Zhu

Hong Ren

Yueniu Zhu

Gangfeng Yan

Chunxia Wang

Yucai Zhang

Affiliations

Soon will be listed here.

Abstract

Introduction: Multiple organ dysfunction syndrome (MODS) with secondary hemophagocytic lymphohistiocytosis (SHLH) causes significant mortality. We aimed to identify the predictor factors for death in pediatric patients with SHLH-associated MODS receiving continuous renal replacement therapy (CRRT).

Methods: This multicentered nested case-control study was conducted from 2016 to 2020. The characteristics were compared between survivors and non-survivors. Logistic regression was applied to identify the risk factors for death. The cutoff values were assessed by receiver operating characteristics curves.

Results: Fifty two patients were enrolled in this study. Interleukin-6 level (p = 0.018) and the number of organ dysfunction (p = 0.047) were independent risk factors for death. The cutoff value of 13.12 pg/ml interleukin-6 and three organs dysfunction at CRRT initiation presented a high sensitivity and specificity.

Conclusion: The number of organ dysfunction and interleukin-6 at CRRT initiation are independent risk factors for death in pediatric patients with SHLH-associated MODS.

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Prognostic death factors in secondary hemophagocytic lymphohistiocytosis children with multiple organ dysfunction syndrome receiving continuous renal replacement therapy: A multicenter prospective nested case-control study.

Cui Y, Shi J, Lu G, Wang Y, Zhu X, Ren H Ther Apher Dial. 2021; 26(5):1023-1029.

PMID: 34877787 PMC: 9540864. DOI: 10.1111/1744-9987.13775.

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