Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation the Pentose Phosphate Pathway in Infertility Patient Endometria

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Dec 6

PMID 34867831

Citations 10

Authors

Yingxin Zheng

Yuemeng Zhu

Ting Zhuge

Bin Li

Chao Gu

Affiliations

Soon will be listed here.

Abstract

Estrogen therapy is widely used as a supplementary treatment after hysteroscopy for female infertility patients owing to its protective function that improves endometrial regeneration and menstruation, inhibits recurrent adhesions, and improves subsequent conception rate. The endometrial protective function of such estrogen administration pre-surgery is still controversial. In the current study, 12 infertility patients were enrolled, who were treated with estrogen before hysteroscopy surgery. Using cutting-edge metabolomic analysis, we observed alterations in the pentose phosphate pathway (PPP) intermediates of the patient's endometrial tissues. Furthermore, using Ishikawa endometrial cells, we validated our clinical discovery and identified estrogen-ESR-G6PD-PPP axial function, which promotes estrogen-induced cell proliferation.

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