Regulation of Glucose Metabolism: Effects on Oocyte, Preimplantation Embryo, Assisted Reproductive Technology and Embryonic Stem Cell

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Oct 15

PMID 39403464

Authors

Yu-Ying Xiong

Hai-Ying Zhu

Ruo-Jin Shi

Yun-Feng Wu

Yong Fan

Long Jin

Affiliations

Soon will be listed here.

Abstract

Glucose is a major energy substrate for cellular life activities, and its metabolic pathways include glycolysis, the pentose phosphate pathway, the hexosamine biosynthesis pathway, and the polyol pathway. Here, we review the glucose uptake pathways, metabolic characteristics, glucose transport, glucose metabolism-related enzymes, and biological importance in mammalian oocyte maturation, early embryo development, and embryonic stem cell proliferation and differentiation. Moreover, the interrelationships among glucose metabolism, female reproduction-related diseases and assisted reproductive technologies are focused. In addition, we review a number of analytical methodologies with the intention to integrate a multi-tiered strategy that encompasses cutting-edge metabolomics, artificial intelligence, epigenetics, and morphological assessments, setting the stage for a pivotal approach to cultivating high-caliber embryos in the future.

Citing Articles

Comparison of the Mitophagy and Apoptosis Related Gene Expressions in Waste Embryo Culture Medium of Female Infertility Types.

Kutuk D, Oner C, Basar M, Akcay B, Olcay I, Colak E Life (Basel). 2024; 14(11).

PMID: 39598305 PMC: 11595419. DOI: 10.3390/life14111507.

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