Spatiotemporal Regulation of Store-operated Calcium Entry in Cancer Metastasis

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2021 Dec 2

PMID 34854917

Citations 4

Authors

Fujian Lu

Yunzhan Li

Shengchen Lin

Heping Cheng

Shengyu Yang

Affiliations

Soon will be listed here.

Abstract

The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. There is recent evidence supporting that SOCE is critical for the spatial and the temporal coding of Ca2+ signals in the cell. In this review, we critically examined the spatiotemporal control of SOCE signaling and its implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches to overcome such limitation.

Citing Articles

Convergence of Calcium Channel Regulation and Mechanotransduction in Skeletal Regenerative Biomaterial Design.

LaGuardia J, Shariati K, Bedar M, Ren X, Moghadam S, Huang K Adv Healthc Mater. 2023; 12(27):e2301081.

PMID: 37380172 PMC: 10615747. DOI: 10.1002/adhm.202301081.

Functions and mechanisms of cytosolic phospholipase A in central nervous system trauma.

Zhang H, Chen Y, Hu X, Cai W, Wang X, Ni W Neural Regen Res. 2022; 18(2):258-266.

PMID: 35900400 PMC: 9396495. DOI: 10.4103/1673-5374.346460.

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer.

Wang X, Li Y, Li Z, Lin S, Wang H, Sun J Cancer Res. 2022; 82(12):2254-2268.

PMID: 35413105 PMC: 9203979. DOI: 10.1158/0008-5472.CAN-21-3230.

The Important Role of Ion Transport System in Cervical Cancer.

Chen Y, Shen M Int J Mol Sci. 2022; 23(1).

PMID: 35008759 PMC: 8745646. DOI: 10.3390/ijms23010333.

References

Fukushima M, Tomita T, Janoshazi A, Putney J . Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities. J Cell Sci. 2012; 125(Pt 18):4354-61. PMC: 3516440. DOI: 10.1242/jcs.104919. View

Clapham D . Calcium signaling. Cell. 2007; 131(6):1047-58. DOI: 10.1016/j.cell.2007.11.028. View

Weidinger C, Shaw P, Feske S . STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells. EMBO Mol Med. 2013; 5(9):1311-21. PMC: 3799488. DOI: 10.1002/emmm.201302989. View

Chen Y, Chen Y, Chiu W, Liu K, Liu Y, Chang J . Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors. Cancer Res. 2013; 73(14):4500-9. DOI: 10.1158/0008-5472.CAN-12-4127. View

Boj S, Hwang C, Baker L, Chio I, Engle D, Corbo V . Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015; 160(1-2):324-38. PMC: 4334572. DOI: 10.1016/j.cell.2014.12.021. View

Chen Y, Lai C, Chen Y, Chiu W, Chen H, Shen M . STIM1-dependent Ca signaling regulates podosome formation to facilitate cancer cell invasion. Sci Rep. 2017; 7(1):11523. PMC: 5599537. DOI: 10.1038/s41598-017-11273-2. View

Emrich S, Yoast R, Xin P, Arige V, Wagner L, Hempel N . Omnitemporal choreographies of all five STIM/Orai and IPRs underlie the complexity of mammalian Ca signaling. Cell Rep. 2021; 34(9):108760. PMC: 7968378. DOI: 10.1016/j.celrep.2021.108760. View

Mancarella S, Wang Y, Gill D . Calcium signals: STIM dynamics mediate spatially unique oscillations. Curr Biol. 2009; 19(20):R950-2. PMC: 3601916. DOI: 10.1016/j.cub.2009.08.051. View

Berridge M, Bootman M, Roderick H . Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003; 4(7):517-29. DOI: 10.1038/nrm1155. View

10.

Cui C, Merritt R, Fu L, Pan Z . Targeting calcium signaling in cancer therapy. Acta Pharm Sin B. 2017; 7(1):3-17. PMC: 5237760. DOI: 10.1016/j.apsb.2016.11.001. View

11.

Yang S, Zhang J, Huang X . Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell. 2009; 15(2):124-34. DOI: 10.1016/j.ccr.2008.12.019. View

12.

Lu F, Sun J, Sun T, Cheng H, Yang S . Fluorescence-Based Measurements of Store-Operated Ca Entry in Cancer Cells Using Fluo-4 and Confocal Live-Cell Imaging. Methods Mol Biol. 2018; 1843:63-68. PMC: 6150455. DOI: 10.1007/978-1-4939-8704-7_5. View

13.

Wang S, Song L, Lakatta E, Cheng H . Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature. 2001; 410(6828):592-6. DOI: 10.1038/35069083. View

14.

Zhu H, Zhang H, Jin F, Fang M, Huang M, Yang C . Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget. 2014; 5(11):3455-71. PMC: 4116495. DOI: 10.18632/oncotarget.1903. View

15.

Aytes A, Mollevi D, Martinez-Iniesta M, Nadal M, Vidal A, Morales A . Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. Mol Carcinog. 2011; 51(9):746-53. DOI: 10.1002/mc.20843. View

16.

Parekh A, Putney Jr J . Store-operated calcium channels. Physiol Rev. 2005; 85(2):757-810. DOI: 10.1152/physrev.00057.2003. View

17.

Wei C, Wang X, Chen M, Ouyang K, Song L, Cheng H . Calcium flickers steer cell migration. Nature. 2009; 457(7231):901-5. PMC: 3505761. DOI: 10.1038/nature07577. View

18.

Willoughby D, Everett K, Halls M, Pacheco J, Skroblin P, Vaca L . Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. Sci Signal. 2012; 5(219):ra29. DOI: 10.1126/scisignal.2002299. View

19.

Hogan P . The STIM1-ORAI1 microdomain. Cell Calcium. 2015; 58(4):357-67. PMC: 4564343. DOI: 10.1016/j.ceca.2015.07.001. View

20.

Monteith G, Prevarskaya N, Roberts-Thomson S . The calcium-cancer signalling nexus. Nat Rev Cancer. 2017; 17(6):367-380. DOI: 10.1038/nrc.2017.18. View