The STIM1-ORAI1 Microdomain

Overview

Journal Cell Calcium

Publisher Elsevier

Specialties Cell Biology
Endocrinology

Date 2015 Jul 29

PMID 26215475

Citations 47

Authors

Patrick G Hogan

Affiliations

Soon will be listed here.

Abstract

The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2+) signalling. This review begins with a brief summary of the STIM-ORAI pathway of store-operated Ca(2+) influx, then turns to the special geometry of the STIM-ORAI microdomain and the expected characteristics of the microdomain Ca(2+) signal. A final section of the review seeks to place the STIM-ORAI microdomain into a broader context of cellular Ca(2+) signalling.

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