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Calcium Signaling

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2007 Dec 18
PMID 18083096
Citations 1841
Authors
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Abstract

Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.

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