Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Nov 27

PMID 34835034

Citations 36

Authors

Daniela Krentz

Katharina Zenger

Martin Alberer

Sandra Felten

Michele Bergmann

Roswitha Dorsch

Kaspar Matiasek

Laura Kolberg

Regina Hofmann-Lehmann

Marina L Meli

Andrea M Spiri

Jeannie Horak

Saskia Weber

Cora M Holicki

Martin H Groschup

Yury Zablotski

Eveline Lescrinier

Berthold Koletzko

Ulrich von Both

Katrin Hartmann

Affiliations

Soon will be listed here.

Abstract

Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a common dis-ease in cats, fatal if untreated, and no effective treatment is currently legally available. The aim of this study was to evaluate efficacy and toxicity of the multi-component drug Xraphconn in vitro and as oral treatment in cats with spontaneous FIP by examining survival rate, development of clinical and laboratory parameters, viral loads, anti-FCoV antibodies, and adverse effects. Mass spectrometry and nuclear magnetic resonance identified GS-441524 as an active component of Xraphconn. Eighteen cats with FIP were prospectively followed up while being treated orally for 84 days. Values of key parameters on each examination day were compared to values before treatment initiation using linear mixed-effect models. Xraphconn displayed high virucidal activity in cell culture. All cats recovered with dramatic improvement of clinical and laboratory parameters and massive reduction in viral loads within the first few days of treatment without serious adverse effects. Oral treatment with Xraphconn containing GS-441524 was highly effective for FIP without causing serious adverse effects. This drug is an excellent option for the oral treatment of FIP and should be trialed as potential effective treatment option for other severe coronavirus-associated diseases across species.

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