TNF-alpha, Produced by Feline Infectious Peritonitis Virus (FIPV)-infected Macrophages, Upregulates Expression of Type II FIPV Receptor Feline Aminopeptidase N in Feline Macrophages

Overview

Journal Virology

Specialty Microbiology

Date 2007 Mar 27

PMID 17382365

Citations 43

Authors

Tomomi Takano

Tsutomu Hohdatsu

Ayako Toda

Maki Tanabe

Hiroyuki Koyama

Affiliations

Soon will be listed here.

Abstract

The pathogenicity of feline infectious peritonitis virus (FIPV) is known to depend on macrophage tropism, and this macrophage infection is enhanced by mediation via anti-S antibody (antibody-dependent enhancement, ADE). In this study, we found that TNF-alpha production was increased with viral replication in macrophages inoculated with a mixture of FIPV and anti-S antibody, and demonstrated that this culture supernatant had feline PBMC apoptosis-inducing activity. We also demonstrated that the expression level of the FIPV virus receptor, feline aminopeptidase N (fAPN), was increased in macrophages of FIP cats. For upregulation of TNF-alpha and fAPN in macrophages, viral replication in macrophages is necessary, and their expressions were increased by ADE of FIPV infection. It was demonstrated that a heat-resistant fAPN-inducing factor was present in the culture supernatant of FIPV-infected macrophages, and this factor was TNF-alpha: fAPN expression was upregulated in recombinant feline TNF-alpha-treated macrophages, and FIPV infectivity was increased in these macrophages. These findings suggested that FIPV replication in macrophages increases TNF-alpha production in macrophages, and the produced TNF-alpha acts and upregulates fAPN expression, increasing FIPV sensitivity.

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