Comparative Effects of Enoxacin and Norfloxacin on Human Colonic Microflora

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1987 Nov 1

PMID 3481249

Citations 10

Authors

C Edlund

A Lidbeck

L Kager

C E Nord

Affiliations

Soon will be listed here.

Abstract

Ten healthy volunteers received 400 mg of enoxacin and another ten healthy volunteers received 200 mg of norfloxacin orally twice a day for 7 days. Fecal specimens were collected before, during, and after drug administration to study the impact of enoxacin and norfloxacin on the normal colonic microflora. On day 7, the mean concentrations of enoxacin and norfloxacin were 350 and 950 mg/kg of feces, respectively. Enoxacin and norfloxacin affected the colonic microflora in similar ways. The number of strains of the family Enterobacteriaceae was markedly suppressed during drug administration, whereas the gram-positive and anaerobic microfloras were not significantly altered. Two weeks after withdrawal of the drugs, the colonic microflora had returned to normal.

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References

Heimdahl A, Nord C . Effect of phenoxymethylpenicillin and clindamycin on the oral, throat and faecal microflora of man. Scand J Infect Dis. 1979; 11(3):233-42. DOI: 10.3109/inf.1979.11.issue-3.11. View

Van Der Waaij D . Colonization resistance of the digestive tract: clinical consequences and implications. J Antimicrob Chemother. 1982; 10(4):263-70. DOI: 10.1093/jac/10.4.263. View

Chin N, Neu H . In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrob Agents Chemother. 1983; 24(5):754-63. PMC: 185938. DOI: 10.1128/AAC.24.5.754. View

Adhami Z, Wise R, Weston D, Crump B . The pharmacokinetics and tissue penetration of norfloxacin. J Antimicrob Chemother. 1984; 13(1):87-92. DOI: 10.1093/jac/13.1.87. View

Nord C, Kager L, Heimdahl A . Impact of antimicrobial agents on the gastrointestinal microflora and the risk of infections. Am J Med. 1984; 76(5A):99-106. DOI: 10.1016/0002-9343(84)90250-x. View

Cofsky R, duBouchet L, Landesman S . Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers. Antimicrob Agents Chemother. 1984; 26(1):110-1. PMC: 179930. DOI: 10.1128/AAC.26.1.110. View

Barza M, Giuliano M, Jacobus N, Gorbach S . Effect of broad-spectrum parenteral antibiotics on "colonization resistance" of intestinal microflora of humans. Antimicrob Agents Chemother. 1987; 31(5):723-7. PMC: 174822. DOI: 10.1128/AAC.31.5.723. View

Reeves D, Bywater M, HOLT H . The activity of enoxacin against clinical bacterial isolates in comparison with that of five other agents, and factors affecting that activity. J Antimicrob Chemother. 1984; 14 Suppl C:7-17. DOI: 10.1093/jac/14.suppl_c.7. View

Davies B, MAESEN F, Teengs J . Serum and sputum concentrations of enoxacin after single oral dosing in a clinical and bacteriological study. J Antimicrob Chemother. 1984; 14 Suppl C:83-9. DOI: 10.1093/jac/14.suppl_c.83. View

10.

Brumfitt W, Franklin I, Grady D, Hamilton-Miller J, Iliffe A . Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers. Antimicrob Agents Chemother. 1984; 26(5):757-61. PMC: 180008. DOI: 10.1128/AAC.26.5.757. View

11.

Rozenberg-Arska M, Dekker A, Verhoef J . Ciprofloxacin for selective decontamination of the alimentary tract in patients with acute leukemia during remission induction treatment: the effect on fecal flora. J Infect Dis. 1985; 152(1):104-7. DOI: 10.1093/infdis/152.1.104. View

12.

Van Saene J, Van Saene H, Geitz J, Lerk C . Quinolones and colonization resistance in human volunteers. Pharm Weekbl Sci. 1986; 8(1):67-71. DOI: 10.1007/BF01975484. View

13.

Bergan T, Delin C, Johansen S, Kolstad I, Nord C, Thorsteinsson S . Pharmacokinetics of ciprofloxacin and effect of repeated dosage on salivary and fecal microflora. Antimicrob Agents Chemother. 1986; 29(2):298-302. PMC: 176395. DOI: 10.1128/AAC.29.2.298. View

14.

Bauernfeind A, Ullmann U . In-vitro activity of enoxacin, ofloxacin, norfloxacin and nalidixic acid. J Antimicrob Chemother. 1984; 14 Suppl C:33-8. DOI: 10.1093/jac/14.suppl_c.33. View