In-vitro Activity of Enoxacin, Ofloxacin, Norfloxacin and Nalidixic Acid

Overview

Journal J Antimicrob Chemother

Publisher Oxford University Press

Specialty Infectious Diseases

Date 1984 Sep 1

PMID 6238931

Citations 21

Authors

A Bauernfeind

U Ullmann

Affiliations

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Abstract

The in-vitro activity of enoxacin, ofloxacin, norfloxacin and nalidixic acid was determined against 1499 Gram-negative and 279 Gram-positive isolates from different clinical institutions in the Federal Republic of Germany. 90% of all Enterobacteriaceae were inhibited by 0.5 mg/l. Glucose non-fermenting Gram-negative rods and staphylococci were less sensitive to all 4-quinolones. All Gram-negative strains selected for resistance to nalidixic acid were significantly less sensitive to the new generation of 4-quinolones tested.

Citing Articles

Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections.

Patel S, Spencer C Drugs. 1996; 51(1):137-60.

PMID: 8741236 DOI: 10.2165/00003495-199651010-00009.

The place of quinolones in antibacterial therapy in hospitals.

Mouton R Pharm Weekbl Sci. 1986; 8(1):72-8.

PMID: 3960694 DOI: 10.1007/BF01975485.

Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Holmes B, Brogden R, Richards D Drugs. 1985; 30(6):482-513.

PMID: 3908074 DOI: 10.2165/00003495-198530060-00003.

Determination of norfloxacin and ciprofloxacin concentrations in serum and urine by high-pressure liquid chromatography.

Morton S, Shull V, Dick J Antimicrob Agents Chemother. 1986; 30(2):325-7.

PMID: 3767345 PMC: 180544. DOI: 10.1128/AAC.30.2.325.

[Enoxacin: spectrum and activity of its antibacterial effect].

Bauernfeind A, Flamm H, Grimm H, Hahn H, KAYSER F, Opferkuch W Infection. 1986; 14 Suppl 3:S188-90.

PMID: 3531028 DOI: 10.1007/BF01667841.