SNX10 and Caspase-5 Sort out Endosomal LPS for a Gut-wrenching Slug-fest

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2021 Nov 19

PMID 34796973

Citations 3

Authors

Mary S Dickinson

Jorn Coers

Affiliations

Soon will be listed here.

Abstract

Endosomes are important cellular compartments for sorting internalized cargo and immune sensing. In this issue, Wang et al describe a novel signaling pathway induced by endocytosed bacterial outer membrane vesicles, where sorting nexin 10 and caspase-5 act at the endosome to promote cytosolic exposure of LPS and initiate signaling to alter epithelial layer integrity. This study presents the first example of a specialized function for caspase-5, distinct from the inflammasome function executed by the closely related paralog caspase-4.

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SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest.

Dickinson M, Coers J EMBO J. 2021; 40(24):e110128.

PMID: 34796973 PMC: 8672184. DOI: 10.15252/embj.2021110128.

References

Finethy R, Dockterman J, Kutsch M, Orench-Rivera N, Wallace G, Piro A . Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020; 21(11):e50830. PMC: 7645254. DOI: 10.15252/embr.202050830. View

Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P . Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014; 514(7521):187-92. DOI: 10.1038/nature13683. View

Dickinson M, Coers J . SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest. EMBO J. 2021; 40(24):e110128. PMC: 8672184. DOI: 10.15252/embj.2021110128. View

Nakamura N, Lill J, Phung Q, Jiang Z, Bakalarski C, De Maziere A . Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature. 2014; 509(7499):240-4. DOI: 10.1038/nature13133. View

Finethy R, Luoma S, Orench-Rivera N, Feeley E, Haldar A, Yamamoto M . Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. mBio. 2017; 8(5). PMC: 5626967. DOI: 10.1128/mBio.01188-17. View

Vanaja S, Russo A, Behl B, Banerjee I, Yankova M, Deshmukh S . Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Cell. 2016; 165(5):1106-1119. PMC: 4874922. DOI: 10.1016/j.cell.2016.04.015. View

Serrano-Gomez S, Maziveyi M, Alahari S . Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer. 2016; 15:18. PMC: 4765192. DOI: 10.1186/s12943-016-0502-x. View

Bitto N, Baker P, Dowling J, Wray-McCann G, De Paoli A, Tran L . Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes. Immunol Cell Biol. 2018; 96(10):1120-1130. DOI: 10.1111/imcb.12190. View

You Y, Zhou C, Li D, Cao Z, Shen W, Li W . Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis. Sci Rep. 2016; 6:20630. PMC: 4746623. DOI: 10.1038/srep20630. View

10.

Knodler L, Crowley S, Sham H, Yang H, Wrande M, Ma C . Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe. 2014; 16(2):249-256. PMC: 4157630. DOI: 10.1016/j.chom.2014.07.002. View

11.

Eren E, Planes R, Bagayoko S, Bordignon P, Chaoui K, Hessel A . Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response. EMBO Rep. 2020; 21(11):e50829. PMC: 7645206. DOI: 10.15252/embr.202050829. View

12.

Wang X, Ni J, You Y, Feng G, Zhang S, Bao W . SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. EMBO J. 2021; 40(24):e108080. PMC: 8672282. DOI: 10.15252/embj.2021108080. View

13.

Rutherford A, Traer C, Wassmer T, Pattni K, Bujny M, Carlton J . The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci. 2006; 119(Pt 19):3944-57. PMC: 1904490. DOI: 10.1242/jcs.03153. View